Research the possibility of the traditional Japanese medicine"Rikkunshito" as the calorie restriction mimetic drug

研究日本传统药物“六君子”作为卡路里限制模拟药物的可能性

• 批准号: 22790620
• 负责人: KOMATSU Toshimitsu
• 金额: $ 2.5万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790620/
• 关键词: 東洋医学; カロリー制限; 抗老化

Short term treatment of traditional Japanese medicine “Rikkunshito (RKT)” increases plasma acyl-ghrelin, and stimulates food intake via hypothalamic NPY expression. This mechanism is similar to that of calorie restriction (CR). In this study, we investigated the possibility of RKT as the calorie restriction mimetic drug. Chronic RKT treatment increased acyl-ghrelin level, and enhanced oxidative stress resistance like the effect of CR. However, chronic RKT treatment could not extend lifespan. Interestingly, chronic RKT treatment from middle or old age significantly decreased white adipose tissue mass.Although it is necessary to clear more detail condition and molecular mechanisms of RKT treatment at the old age model, it is expected to apply anti-obesity drug.

传统日本药物“Rikkunshito (RKT)”血浆的短期治疗会增加酰基生长素释放肽，并通过下丘脑 NPY 表达刺激食物摄入。这种机制类似于热量限制 (CR)。 RKT 作为热量限制模拟药物，慢性 RKT 治疗会增加酰基生长素释放肽水平，并增强氧化应激抵抗力，就像 CR 的效果一样。治疗不能延长寿命，中老年长期RKT治疗显着减少白色脂肪组织量。虽然有必要明确老年模型RKT治疗的更多细节条件和分子机制，但预计可以应用在老年模型中。 - 减肥药。

项目成果

Modulators of neuropeptide Y; potential dietary restriction mimetics

神经肽Y调节剂；

• 发表时间: 2012
• 作者: Yamaza H;Komatsu T;et al;Isao Shimokawa
• 通讯作者: Isao Shimokawa

FoxO1 is involved in the antineoplastic effect of calorie restriction

• DOI: 10.1111/j.1474-9726.2010.00563.x
• 发表时间: 2010-06
• 期刊: Aging Cell
• 影响因子: 7.8
• 作者: H. Yamaza;Toshimitsu Komatsu;Saori Wakita;Carole Kijogi;Seongjoon Park;H. Hayashi;T. Chiba;Ryoichi Mori;T. Furuyama;N. Mori;I. Shimokawa

Does a traditional Japanese medicine "Rikkunshito" promote stress resistance like calorie restriction?

日本传统药物“六君子”是否可以像限制热量一样促进抗压能力？

• 发表时间: 2011
• 作者: Taisuke Kasuya;Toshimitsu Komatsu
• 通讯作者: Toshimitsu Komatsu

Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species geeration or redox state, unlike calorie restriction

与热量限制不同，生长激素轴的适度抑制不会影响线粒体活性氧的生成或氧化还原状态

• 发表时间: 2011
• 期刊: Geriatr Gerontol Int
• 影响因子: 3.3
• 作者: Hayashida T;Komatsu T;et al
• 通讯作者: et al

Does a traditional Japanese medicine "Rikkunshito" mimic effects of calorie restriction?

日本传统药物“六君子”是否模仿热量限制的效果？

• 发表时间: 2011
• 作者: Yuko Nagatomi;Toshimitsu Komatsu
• 通讯作者: Toshimitsu Komatsu