The effects of continuing and discontinuing smoking on the renalfunction in middle-aged healthy Japanese men and women

继续吸烟和戒烟对日本中年健康男性和女性肾功能的影响

• 批准号: 22590612
• 负责人: YAMADA Yuichi
• 金额: $ 2.91万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590612/
• 关键词: 喫煙; 腎機能障害; 日本人

The aims of the studies are to reveal the effects of smoking on the renal function in Japanese, and to clarify the biological significance of the contradictory high GFR in smokers observed in the previous studies. The associations of smoking with the appearance of proteinuria, the decline of GFR and the development of CKD were observed cross-sectionally and longitudinally in 2,000 workers of a chemical factory and in 7,000 workers who undertook health check-ups. The studies revealed that smoking is a significant factor of the development of CKD, and quitting it reduces the risk. Long observation is required to reveal the fate of high GFR in smokers. Further, serum GGT and blood pressure are remarkably high in smokers having CKD, which may relate to the progression of CDK in smokers.

研究的目的是揭示吸烟对日本肾功能的影响，并阐明在先前研究中观察到的吸烟者中矛盾的高GFR的生物学意义。在2,000名化学工厂的工人和7,000名进行健康检查的工人中，观察到吸烟与蛋白尿外观，GFR的下降和CKD的发展的关联。研究表明，吸烟是CKD发展的重要因素，并戒烟会降低风险。需要长时间观察才能揭示吸烟者中高GFR的命运。此外，患有CKD的吸烟者的血清GGT和血压非常高，这可能与吸烟者中CDK的进展有关。

项目成果

Risk factors related to the development of chronic kidney disease (CKD) in middle-aged workers.

与中年工人患慢性肾病（CKD）相关的危险因素。

• 发表时间: 2013
• 作者: Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata;Y.Noborisaka M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Yuka Noborisaka;Yuka Noborisaka;Y.Yamada,Y.Noborisaka,M.Ishizaki,R.Honda,H.Yokoyama,M.Tabata,M.Miyao.
• 通讯作者: Y.Yamada,Y.Noborisaka,M.Ishizaki,R.Honda,H.Yokoyama,M.Tabata,M.Miyao.

The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan

• DOI: 10.1007/s12199-012-0285-7
• 发表时间: 2013-01-01
• 期刊: ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
• 影响因子: 4.7
• 作者: Noborisaka, Yuka;Ishizaki, Masao;Tabata, Masaji
• 通讯作者: Tabata, Masaji

明らかな腎疾患をもたない日本人中年男性での喫煙と腎機能障害の関係

无明显肾病的日本中年男性吸烟与肾功能障碍的关系

• 发表时间: 2011
• 作者: 登坂由香;山田裕一;石崎昌夫;本多隆文;田畑正司;宮尾克;末吉秀二;登坂由香
• 通讯作者: 登坂由香

労働者の慢性腎疾患評価法の検討(1)クレアチニンとシスタチンCによるeGFR.

工人慢性肾病评估方法的检验（1）使用肌酐和胱抑素C的eGFR。

• 发表时间: 2013
• 作者: 登坂由香;山田裕一;石崎昌夫;本多隆文;田畑正司;宮尾克
• 通讯作者: 宮尾克

Risk factors related to the development of chronic kidney disease (CKD) in middle-aged workers

中年工人患慢性肾脏病（CKD）的相关危险因素

• 作者: 登坂由香;山田裕一;石崎昌夫;本多隆文;田畑正司;宮尾克;末吉秀二;登坂由香;末吉秀二;Yuichi Yamada
• 通讯作者: Yuichi Yamada