Genetic polymorphisms in alcohol metabolizing enzyme and alcohol-induced health effects.

酒精代谢酶的遗传多态性和酒精引起的健康影响。

基本信息

批准号：
07670414
负责人：
YAMADA Yuichi
金额：
$ 1.41万
依托单位：
Department of Hygiene, Kanazawa Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670414/
关键词：
cytochrome P450-2E1 genotype Japanese alcohol bood pressure serum uric acid P4502El hepatic enzymes serum lipids uric acid

项目摘要

Three-hundred-and-sixty-seven unrelated Japanese male workers aged between 36 and 61 years were analyzed for the genotypes of cytochrome P450 2E1 (CYP2E1), and the association with alcohol-related health effects including blood pressure (BP) elevation. Homozygous for the cl (wild) gene was found in 204 men (55%), homozygous for the c2 (variant) gene in 17 (5%), and heterozygous in 146 (40%). Arithmetic means of alcohol consumed per week in the genotypes of cl/cl, cl/c2 and c2/c2 were 218,257 and 211g, respectively, and were not statistically different. BP was elevated with the increase in alcohol consumption, and was significantly higher in the c2/c2 genotype than in the other genotypes among the subjects consuming 200g or more of alcohol per week. Serum uric acid did not correlate with alcohol consumption in the whole subjects, but it was also higher in drinkers having the c2/c2 genotype. Although the number of subjects was too small for a definite conclusion to be drawn, these results suggest to some extent that Japanese men having the c2/c2 genotype of CYP2E1 are more sensitive to the pressor effect of alcohol. Further studies are required to confirm this. Key words : alcohol, blood pressure, cytochrome P450 2E1, genotype, Japanese.

研究人员对 367 名年龄在 36 岁至 61 岁之间的无亲属关系的日本男性工人进行了细胞色素 P450 2E1 (CYP2E1) 基因型分析，以及与酒精相关健康影响（包括血压 (BP) 升高）的关系。 204 名男性 (55%) 发现了 cl（野生）基因纯合子，17 名男性（5%）发现了 c2（变异）基因纯合子，146 名男性（40%）发现了杂合子。 cl/cl、cl/c2和c2/c2基因型每周饮酒量的算术平均值分别为218,257和211g，没有统计学差异。血压随着饮酒量的增加而升高，并且在每周饮酒200g或更多的受试者中，c2/c2基因型的血压显着高于其他基因型。整个受试者的血清尿酸与饮酒量无关，但具有 c2/c2 基因型的饮酒者的血清尿酸也较高。尽管受试者数量太少，无法得出明确的结论，但这些结果在一定程度上表明，CYP2E1 c2/c2 基因型的日本男性对酒精的升压作用更敏感。需要进一步的研究来证实这一点。关键词：酒精、血压、细胞色素 P450 2E1、基因型、日语。