Development of osteoconductive materials using ion conductive ceramics

使用离子导电陶瓷开发骨传导材料

• 批准号: 15360338
• 负责人: NAKAMURA Satoshi
• 金额: $ 9.73万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15360338/
• 关键词: Hydroxyapatite; Ionic conductivity; Polarization; Oteoconductivity; Surface charges; Bioactive glass; Zirconia; Early stage cell adhesion; 電気分極; 骨組織伝導; セラミックス; 初期接着; 吸着; 細胞外基質

Large surface charges were demonstrated to be inducible on ionic conductive ceramics by ion transport polarization based on thermally stimulated depolarization measurements. We have been demonstrated by simulated body fluid tests that the negative, surface charges induced by the electrical polarization increased the overgrowth conductivity on the ionic conductive ceramic surface but that the positive charge diminished the overgrowth ability. The charge-induced surfaces of the ionic conductive ceramics promoted bone reconstructions in wide defects of canine bones at 7days after the implantation, whereas the processes varied according to the charge polarity. The idea of the activated field concerning the in vitro overgrowth should be extensible into the in vivo calcification reactions of the electrically polarized ionic conductive ceramics implanted in bone tissues. Moreover, we have proved that the electrical polarization techniques were applicable not only to hydroxyapatite but also to zirconia and bioactive glass and established the electrical polarization technologies for ionic conductive ceramics.

事实证明，基于热刺激去极化测量的离子传输极化可以在离子导电陶瓷上诱导大表面电荷。我们通过模拟体液测试证明，电极化引起的负表面电荷增加了离子导电陶瓷表面的过度生长电导率，但正电荷减弱了过度生长能力。植入后7天，离子导电陶瓷的电荷感应表面促进了犬骨大面积缺损的骨重建，但该过程根据电荷极性而变化。关于体外过度生长的激活场的想法应该可以扩展到植入骨组织中的电极化离子导电陶瓷的体内钙化反应。此外，我们还证明了电极化技术不仅适用于羟基磷灰石，也适用于氧化锆和生物活性玻璃，并建立了离子导电陶瓷的电极化技术。

项目成果

Synthesis of Bioactive Zirconia Ceramics on the Basis of Vector Materials Science

基于载体材料科学的生物活性氧化锆陶瓷的合成

• 发表时间: 2005
• 作者: Yamashita K; Nakamura S; Kishi S; Inuzuka M; Nishio K; Hashimoto K; Toda Y
• 通讯作者: Toda Y

Electrical Polarization of Plasma-spray-hydroxyapatite Coatings for Improvement of Osteoconduction of Implants

等离子喷涂羟基磷灰石涂层的电极化用于改善植入物的骨传导

• 发表时间: 2005
• 作者: Kato R; Nakamura S; Katayama K; Yamashita K.
• 通讯作者: Yamashita K.

Effective cell adhesion and proliferation on electrically polarized hydroxyapatite surfaces in body fluid

体液中电极化羟基磷灰石表面的有效细胞粘附和增殖

• 发表时间: 2005
• 作者: Arai H; Kobayashi T; Nakamura M; Sekijima Y; Nakamura S; Yamashita K
• 通讯作者: Yamashita K

Osseous Cell Response to Electrostatic Stimulations of Poled Hydroxyapatite Ceramics in Canine Diaphyses

犬骨干中极化羟基磷灰石陶瓷静电刺激的骨细胞反应

• 发表时间: 2004
• 作者: Nakamura S; Nakamura M; Kobayashi T; Sekijima Y; Kasugai S; Yamashita K.
• 通讯作者: Yamashita K.

Octacalcium Phosphate-Based Cement as a Pulp-Capping Agent in Rats

磷酸八钙水泥作为大鼠盖髓剂

• 发表时间: 2004
• 作者: Sena M; Yamashita Y; Nakano Y; Ohgaki M; Nakamura S; Yamashita K.
• 通讯作者: Yamashita K.