Endothelial cell rescue therapy of multiorgan failure after severe sepsis

严重脓毒症后多器官衰竭的内皮细胞挽救治疗

基本信息

批准号：
22390337
负责人：
ISOTANI Eiji
金额：
$ 5.41万
依托单位：
Tokyo Women's Medical University (2011-2012)Tokyo Medical and Dental University (2010)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Introduction: It is expected that recombinant human soluble thrombomodulin (rTM) not only reverses hyper-coagulative status through activating protein C but also prevents multiple organ failure. rTM may improve both physiological scores and the amount of mediators, and reduces the mortality of sepsis and DIC patients in 28 days. We started a new protocol by adding rTM for sepsis and disseminated intravascular coagulation patients. We introduce the preliminary report in this paper.Material & Methods: We enrolled and analyzed 21 patients who were treated for DIC accompanied by sepsis from May to October 2008. Our primary endpoint was mortality in 28 days. As composite outcomes, we followed Acute Physiology and Chronic Health Evaluation (APATCHE II) score, Sequential Organ Failure Assessment (SOFA) score, acute phase DIC score, and serum soluble thrombomodulin, TNF-α, IL-1β, IL-6, HMGB-1, protein C, protein S levels during 10 days. Statistical analysis was performed by Wilcoxon rank-sum test. P < 0.05 was regarded as statistically significant.Results: We found that all scores and mediators improved after administration of rTM in Day 10, but there was no significant improvement in at 28 days. Median of each score or mortality was as follows; APATCH II score: 32 at Day 1 to 26 at Day 10 (p=0.0048), SOFA score: 12 to 8 (p=0.0096), acute phase DIC score: 5 to 3 (p

简介：预计重组人固体血栓形成蛋白（RTM）不仅可以通过激活蛋白C逆转超凝的状态，而且还可以防止多器官衰竭。 RTM可以提高身体评分和介体的数量，并在28天内降低败血症和DIC患者的死亡率。我们通过添加用于败血症和散布血管内凝血患者的RTM来启动新方案。我们在本文中介绍了初步报告。材料和方法：我们从2008年5月至2008年10月进行了由败血症完成的DIC治疗的21例患者。我们的主要终点是28天内的死亡率。作为复合结果，我们遵循急性生理学和慢性健康评估（Apatche II）得分，顺序器官失效评估（SOFA）得分，急性相DIC评分和血清可溶性血栓瘤蛋白，TNF-α，IL-1β，IL-1β，IL-6，HMGB-1，HMGB-1，蛋白质C，蛋白质C，蛋白质C，蛋白质S水平在10天内。统计分析是通过Wilcoxon Rank-sum检验进行的。 p <0.05被认为具有统计学意义。分子：我们发现，在第10天使用RTM后，所有分数和调解人都改善了，但在28天时没有显着改善。每个分数或死亡率的中位数如下； Apatch II分数：第1天至26天32（p = 0.0048），沙发分数：12至8（p = 0.0096），急性相DIC分数：5至3（P