Elucidation of molecular mechanism of plaque destabilization and identification of predictable factors for acute coronary syndrome

阐明斑块不稳定的分子机制并确定急性冠状动脉综合征的可预测因素

• 批准号: 22390159
• 负责人: SATA Masataka
• 金额: $ 11.98万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390159/
• 关键词: 動脈硬化; 血管新生; 慢性炎症; HMGB-1; 急性冠症候群プラーク破裂; 循環器・高血圧; 急性冠症候群; プラーク破裂; プラーク; 自然免疫; マクロファージ; サイトカイン; 生活習慣病

We tried to elucidate molecular mechanism of plaque destabilization by analyzing clinical samples and utilizing animal models. The concentration of HMGB1, a non-histone nuclear protein, increased at coronary sinus in patients with coronary artery disease. Particularly, acute coronary syndrome, such as acute myocardial infarction or unstable angina pectoris, was associated with ten times elevated HMGB1 level. Animal experiments revealed that HMGB1-DNA complex signal contributed destabilization of vessel wall by activating Toll-like receptor 9 in the bone marrow-derived cells.

我们试图通过分析临床样本并利用动物模型来阐明牙菌斑不稳定的分子机制。冠状动脉疾病患者的冠状窦中HMGB1的浓度（一种非固定核蛋白）增加。特别是，急性冠状动脉综合征，例如急性心肌梗塞或不稳定的心绞痛，与HMGB1水平升高十倍。动物实验表明，HMGB1-DNA复合物信号通过激活骨髓衍生细胞中的Toll样受体9来促进血管壁的不稳定。

项目成果

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling

• DOI: 10.1016/j.yjmcc.2010.09.024
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Kim-Kaneyama, Joo-ri;Takeda, Naoki;Nose, Kiyoshi
• 通讯作者: Nose, Kiyoshi

Ultrasonic Tissue Characterization of Carotid Artery Plaque using High-resolution Integrated Backscatter Imaging ; Validation Study with Histological Correlation

使用高分辨率集成反向散射成像对颈动脉斑块进行超声组织表征；

• 发表时间: 2011
• 作者: Bando;M.;et al
• 通讯作者: et al

Women are different: the role of coupling factor 6 in blood pressure regulation.

• DOI: 10.1038/hr.2012.9
• 发表时间: 2012-05
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: de Castro Bras, Lisandra E.;DeLeon, Kristine Y.;Lindsey, Merry L.
• 通讯作者: Lindsey, Merry L.

Bosentan Ameliorated Exercise-Induced Pulmonary Arterial Hypertension Complicated with Systemic Sclerosis

• DOI: 10.2169/internalmedicine.49.3812
• 发表时间: 2010-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Yagi, Shusuke;Akaike, Masashi;Sata, Masataka
• 通讯作者: Sata, Masataka

Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.

稳定型心绞痛患者植入西罗莫司洗脱支架后局部持续高凝状态。

• DOI: 10.1016/j.ijcard.2010.08.014
• 发表时间: 2011
• 期刊: Int J Cardiol.
• 作者: Yamaguchi K;Wakatsuki T;Niki T;Kusunose K;Koshiba K;Yagi S;Taketani Y;Iwase T;Tomita N;Yamada H;Soeki T;Akaike M;Sata M
• 通讯作者: Sata M