Development of a novel treatment for coronary artery diseases by replacement of the epicardial adipose tissue

通过替代心外膜脂肪组织开发治疗冠状动脉疾病的新方法

• 批准号: 23659420
• 负责人: SATA Masataka
• 金额: $ 2.5万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659420/
• 关键词: 動脈硬化; 脂肪; 移植; 炎症; 外膜; 血管新生

We demonstrated chronic inflammation in epicardial adipose tissues obtained from patients with coronary artery disease. Replacement of pericardial adipose tissues effectively reduced neointima formation after endovascular injury. Based upon these results, we are developing new cardiac bypass surgery by transplanting subcutaneous adipose tissues.

我们证明了从冠状动脉疾病患者获得的心外膜脂肪组织的慢性炎症。替代心包脂肪组织有效地减少了血管内损伤后的新内膜形成。基于这些结果，我们通过移植皮下脂肪组织来开发新的心脏搭桥手术。

项目成果

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling

• DOI: 10.1016/j.yjmcc.2010.09.024
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• 影响因子: 5
• 作者: Kim-Kaneyama, Joo-ri;Takeda, Naoki;Nose, Kiyoshi
• 通讯作者: Nose, Kiyoshi

Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.

稳定型心绞痛患者植入西罗莫司洗脱支架后局部持续高凝状态。

• DOI: 10.1016/j.ijcard.2010.08.014
• 发表时间: 2011
• 期刊: Int J Cardiol.
• 作者: Yamaguchi K;Wakatsuki T;Niki T;Kusunose K;Koshiba K;Yagi S;Taketani Y;Iwase T;Tomita N;Yamada H;Soeki T;Akaike M;Sata M
• 通讯作者: Sata M

Deteriorationof right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model : echocardiographic evaluation by 2D speckle tracking

野百合碱诱导的肺动脉高压犬模型中右心室心肌收缩功能的恶化：通过二维斑点追踪进行超声心动图评估

• 发表时间: 2011
• 作者: Nishio;S;et al
• 通讯作者: et al

Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model : echocardiographic evaluation by 2D speckle tracking

野百合碱诱导的肺动脉高压犬模型中右心室心肌收缩功能的恶化：通过二维斑点追踪进行超声心动图评估

• 发表时间: 2011
• 作者: Nishio;S.;Yamada;H.;Tamai;R.;Endo;K.;Hayashi;S.;Kusunose;K.;Soeki;T.;Wakatsuki;T.;Sakai;Y.;Sata;M.
• 通讯作者: M.

Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension

自适应伺服通气对肺动脉高压患者的急性血流动力学影响

• DOI: 10.1016/j.ijcard.2011.01.074
• 发表时间: 2011
• 期刊: Int J Cardiol
• 影响因子: 3.5
• 作者: Akiyoshi Ogimoto;Jun Suzuki;Katsuji Inoue;Kazuhisa Nishimura;Takayuki Nagai;Yuji Shigematsu;Hideki Okayama;Jitsuo Higaki.;赤池雅史
• 通讯作者: 赤池雅史