Serum DNase I activity can be a useful biomarker for the early diagnosis of transient myocardial ischemia

血清 DNase I 活性可作为早期诊断短暂性心肌缺血的有用生物标志物

• 批准号: 21659146
• 负责人: UEKI Misuzu
• 金额: $ 2.23万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659146/
• 关键词: 心筋虚血; DNase I; 診断マーカー; SNP; DNase family; 遺伝子型-活性相関; deoxyribonuclease I; 非ST上昇型急性心筋梗塞; 不安定狭心症; 一過性心筋虚血; deoxyribonuclease I-like 3; deoxyribonuclease II; 集団調査; 急性冠症候群; 低酸素応答

The aim of this study was to evaluate utilization of serum DNase I as a novel diagnostic biomarker of transient myocardial ischemia ;(1) A high diagnostic efficacy of serum DNase I activity levels could be observed in the early phase, even in unstable pectoris or non-ST segment elevation myocardial infarction patients who did not show elevation of conventional cardiac biomarkers. Thus, serum DNase I activity can be a useful biomarkers for the early diagnosis of these diseases inducing a transient myocardial ischemia after the onset of chest pain.(2) A transient elevation of the serum DNase I activity induced by a myocardial ischemia could in partial result from hypoxia-response of DNase I gene.(3) In non-synonymous SNPs of DNase I and I-like 3 genes, specific alleles producing an inactive/low activity-harboring enzyme were found. These alleles might be one of several factors involved in genetic predisposition to autoimmune diseases.

这项研究的目的是评估血清DNase I作为瞬态心肌缺血的新型诊断生物标志物；（1）在早期阶段，即使在不稳定的胸膜或非STEM段高脑梗死患者中，也可以在早期观察到血清DNase I活性水平的高诊断功效。 Thus, serum DNase I activity can be a useful biomarkers for the early diagnosis of these diseases inducing a transient myocardial ischemia after the onset of chest pain.(2) A transient elevation of the serum DNase I activity induced by a myocardial ischemia could in partial result from hypoxia-response of DNase I gene.(3) In non-synonymous SNPs of DNase I and发现了类似3的基因，特定的等位基因，产生了无活性/低活性 - 养成酶。这些等位基因可能是自身免疫性疾病遗传易感性易感性涉及的几个因素之一。

项目成果

Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population

• DOI: 10.1002/cbf.1572
• 发表时间: 2009-07-01
• 期刊: CELL BIOCHEMISTRY AND FUNCTION
• 影响因子: 3.6
• 作者: Iida, Reiko;Ueki, Misuzu;Yasuda, Toshihiro
• 通讯作者: Yasuda, Toshihiro

Deoxyribonuclease II (DNase II)遺伝子に座位する非同義置換型SNPには不活性な酵素を産生するminor alleleが分布する

产生无活性酶的次要等位基因分布在位于脱氧核糖核酸酶 II (DNase II) 基因中的非同义取代 SNP 中。

• 发表时间: 2010
• 作者: 藤原純子;木村かおり;竹下治男;中島たみ子;小湊慶彦;湯浅勲;飯田礼子;植木美鈴;安田年博
• 通讯作者: 安田年博

DNASE1 exon 内非同義置換SNP検索

DNASE1 外显子非同义替换 SNP 搜索

• 发表时间: 2010
• 作者: 村田聡;内藤弘之;山本寛;山口剛;来見良誠;谷徹;ほか;藤原純子
• 通讯作者: 藤原純子

低酸素による核酸分解酵素DNASE1遺伝子の発現増加と転写調節

缺氧导致核酸溶解酶 DNASE1 基因的表达和转录调节增加

• 发表时间: 2009
• 作者: 森毅;柳橋健;岡本正吾;林直樹;来見良誠;谷徹;ほか;高木利恵
• 通讯作者: 高木利恵

ヒトSOD1、SOD2およびSOD3遺伝子内の非同義置換型SNPの同時解析

同时分析人类 SOD1、SOD2 和 SOD3 基因中的非同义替换 SNP

• 发表时间: 2011
• 期刊: DNA多型
• 作者: 飯田礼子;他
• 通讯作者: 他