Development of the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis

新型抗肝细胞癌侵袭转移分子靶向治疗药物的研究进展

• 批准号: 21791288
• 负责人: KOBAYASHI Tsuyoshi
• 金额: $ 2.58万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791288/
• 关键词: 癌; 遺伝子; 蛋白質; 細胞・組織; 外科

The aim of this study was to develop the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis. Although we were not able to clarify the clinical significance of expression of h-prune in hepatocellular carcinoma, we elucidated that h-prune frequently expressed in thyroid cancers and had an essential role in anaplastic thyroid cancer cell invasion and metastasis.

这项研究的目的是开发针对肝细胞癌侵袭和转移的新型分子靶向疗法。尽管我们无法阐明肝细胞癌中H prune表达的临床意义，但我们阐明了H-Prune在甲状腺癌中经常表达的H-Prune在甲状腺甲状腺癌细胞侵袭和转移中具有至关重要的作用。

项目成果

Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver

• DOI: 10.1016/j.jhep.2011.04.029
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF HEPATOLOGY
• 影响因子: 25.7
• 作者: Kuroda, Shintaro;Tashiro, Hirotaka;Ohdan, Hideki
• 通讯作者: Ohdan, Hideki

Selection Criteria for Hepatectomy in Patients with Hepatocellular Carcinoma Classified as Child-Pugh Class B

• DOI: 10.1007/s00268-010-0929-y
• 发表时间: 2011-04
• 期刊: World Journal of Surgery
• 影响因子: 2.6
• 作者: S. Kuroda;H. Tashiro;Tsuyoshi Kobayashi;A. Oshita;H. Amano;H. Ohdan

肝細胞癌脈管侵襲予測因子の解析

肝细胞癌血管侵犯预测因子分析

• 发表时间: 2009
• 作者: 楠部潤子;小林剛;田代裕尊;杉野圭三;嶋本文雄;大段秀樹;小林剛;小林剛
• 通讯作者: 小林剛

肝細胞癌に対する肝中央二区域切除

中央肝双段切除术治疗肝细胞癌

• 发表时间: 2010
• 作者: 楠部潤子;小林剛;田代裕尊;杉野圭三;嶋本文雄;大段秀樹;小林剛
• 通讯作者: 小林剛

Impact of Pegylated Interferon Therapy on Outcomes of Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma After Curative Hepatic Resection

• DOI: 10.1245/s10434-011-1866-1
• 发表时间: 2012-02-01
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Tanimoto, Yoshisato;Tashiro, Hirotaka;Ohdan, Hideki
• 通讯作者: Ohdan, Hideki