Integrated study on mechanism of development and disorder of masticatory and swallowing function and visualization of neural circuits

咀嚼吞咽功能发育及紊乱机制及神经回路可视化综合研究

• 批准号: 21390549
• 负责人: YOSHIDA Noriaki
• 金额: $ 11.65万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390549/
• 关键词: 咀嚼; 嚥下; 発達; 障害; 咀嚼中枢; 咀嚼機能; 嚥下機能; ノックアウトマウス; 顎運動; 筋電図; 神経機構; 顎口腔機能

A process of development of masticatory and swallowing function was elucidated. As a result, it was suggested that the critical period of development of those functions was beyond 6 weeks of age in mice. Regarding the mechanism of disorder of masticatory and swallowing function, the formation of an abnormal central pattern generator is unlikely to occur. Such a disturbance may be produced at the site inferior to the central pattern generator. The obtained results indicated that neural circuits controlling jaw and tongue movements have a mutual interaction.

阐明了咀嚼和吞咽功能的发育过程。结果表明，小鼠这些功能发育的关键期超过6周龄。关于咀嚼和吞咽功能障碍的机制，不太可能发生异常中枢模式发生器的形成。这种干扰可能在中央图案发生器下方的位置产生。获得的结果表明控制下巴和舌头运动的神经回路具有相互作用。

项目成果

Takano-Yamamoto T : IL-12-and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells

Takano-Yamamoto T：IL-12 和 IL-18 介导的一氧化氮诱导的 TNF-α 介导的骨髓细胞破骨细胞凋亡

• 发表时间: 2011
• 期刊: Calcified Tissue Int
• 影响因子: 4.2
• 作者: Kitaura H;Fujimura Y;Yoshimatsu M;Kohara H;Morita Y;Aonuma T;Fukumoto E;Masuyama R;Yoshida N
• 通讯作者: Yoshida N

Measuring biting behavior induced by acute stress in the rat

• DOI: 10.3758/brm.41.3.761
• 发表时间: 2009-08
• 期刊: Behavior Research Methods
• 影响因子: 5.4
• 作者: J. Zeredo;Y. Kumei;T. Shibazaki;N. Yoshida;K. Toda

An In Vivo 3D Micro-CT Evaluation of Tooth Movement After the Application of Different Force Magnitudes in Rat Molar

• DOI: 10.2319/071308-366.1
• 发表时间: 2009-07-01
• 期刊: ANGLE ORTHODONTIST
• 影响因子: 3.4
• 作者: Gonzales, Carmen;Hotokezaka, Hitoshi;Yoshida, Noriaki
• 通讯作者: Yoshida, Noriaki

Effects of SHIP on TNF-alpha-induced osteoclastogenesis

SHIP 对 TNF-α 诱导的破骨细胞生成的影响

• 发表时间: 2011
• 作者: Yoshimatsu M;Kitaura H;Fujimura Y;Kohara H;Morita Y;Eguchi T;Yoshida N
• 通讯作者: Yoshida N

Decreased Intake of Sucrose Solutions in Orexin Knockout Mice

• DOI: 10.1007/s12031-010-9475-1
• 发表时间: 2011-02-01
• 期刊: JOURNAL OF MOLECULAR NEUROSCIENCE
• 影响因子: 3.1
• 作者: Matsuo, Eiko;Mochizuki, Ayako;Inoue, Tomio
• 通讯作者: Inoue, Tomio