Development of hybrid therapy of myocardial regenerative medicine and ventricular assist circulation to improve prognosis of heart transplant candidate

开发心肌再生医学和心室辅助循环混合疗法以改善心脏移植候选者的预后

• 批准号: 21390398
• 负责人: TAKEWA Yoshiaki
• 金额: $ 11.23万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390398/
• 关键词: 心臓大血管外科学; 心筋再生療法; 遺伝子導入; 重症不全心; カチオン性合成ベクター; 遺伝子デリバリー法; SERCA2a; 左心補助循環; 定常流ポンプ; cross clamping法

We created a heart failure model of large animals (adult goats), conducted a continuous flow left ventricular assist circulation, transferred SERCA2a gene, which can increase the myocardial contractility, and investigated whether this hybrid therapy could improve and recover the cardiac function. In terms of assist circulation, a synchronized alteration of rotational speed of a continuous flow pump was effective to accelerate the myocardial recovery. Additional gene therapy could increase the myocardial contractility. The synergistic effect of ventricular assist and myocardial regenerative medicine showed the potential to improve prognosis of heart failure patients such as heart transplant candidates

我们创建了大型动物（成年山羊）的心力衰竭模型，进行了连续的左心室辅助循环，转移了SERCA2A基因，可以增加心肌收缩性，并研究了这种杂种疗法是否可以改善和恢复心脏功能。在辅助循环方面，连续流动泵的旋转速度的同步变化有效地加速了心肌恢复。其他基因疗法可能会增加心肌收缩力。心室辅助和心肌再生医学的协同作用表明有可能改善心力衰竭患者的预后，例如心脏移植候选者

项目成果

Effect of the technique for assisting renal blood circulation on ischemic kidney in acute cardiorenal syndrome.

肾血循环辅助技术对急性心肾综合征缺血性肾脏的影响

• DOI: 10.1007/s10047-011-0613-5
• 发表时间: 2012
• 期刊: J Artif Organs
• 影响因子: 1.3
• 作者: Hanada S;Takewa Y;Mizuno T;Tsukiya T;Taenaka Y;Tatsumi E.
• 通讯作者: Tatsumi E.

Development of a preclinical model of ischemic cardiomyopathy in swine

• DOI: 10.1152/ajpheart.01103.2010
• 发表时间: 2011-08-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
• 影响因子: 4.8
• 作者: Ishikawa, Kiyotake;Ladage, Dennis;Kawase, Yoshiaki
• 通讯作者: Kawase, Yoshiaki

Flow rate monitoring for a pneumatic VAD using the driveline air mass flow

使用传动系统空气质量流量监测气动 VAD 的流量

• 作者: Kentaro Ohnuma;Hirohito Sumikura;Akihiko Homma;Yoshiyuki Taenaka;Eisuke Tatsumi;Yoshiaki Takewa;Toshihide Mizuno;Tomonori Tsukiya;Nobumasa Katagiri;Hiroshi Mukaibayashi;Kazuo Katano
• 通讯作者: Kazuo Katano

バイオバルブ心臓弁の生体外機能・耐久性評価

生物瓣膜心脏瓣膜的体外功能和耐久性评估

• 发表时间: 2012
• 作者: 中山泰秀;住倉博仁;大沼健太郎;武輪能明;巽 英介
• 通讯作者: 巽 英介

Deposition transfection technology using a homopolymer with both thermoresponsive and cationic characters for cardiac gene therapy

使用具有热响应性和阳离子特性的均聚物进行心脏基因治疗的沉积转染技术

• 发表时间: 2011
• 作者: Zhou YM;Takewa Y;Iwai R;Kusakabe S;Kanzaki K;Taenaka Y;Tatsumi E;Nakayama Y
• 通讯作者: Nakayama Y