A comprehensive transcriptome analysis of humanized mouse liver using ultra high density cDNA micro array

使用超高密度 cDNA 微阵列对人源化小鼠肝脏进行全面转录组分析

• 批准号: 21390229
• 负责人: CHAYAMA Kazuaki
• 金额: $ 11.73万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390229/
• 关键词: 肝臓学; 転写; 発現抑制; 発現亢進; cDNA micro array; interferon; IFN誘導遺伝子; GS EA

We investigated a mechanism of continuous infection of hepatitis B and hepatitis C virus with high density microarray using human hepatocyte chimeric mice. Induction of interferon stimulated genes were partially inhibited by each of the two viruses suggesting that these viruses inhibit induction of interferon stimulated genes with different mechanisms

我们使用人肝细胞嵌合小鼠，通过高密度微阵列研究了乙型肝炎和丙型肝炎病毒持续感染的机制。两种病毒均部分抑制干扰素刺激基因的诱导，表明这些病毒以不同的机制抑制干扰素刺激基因的诱导

项目成果

Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b

• DOI: 10.1016/j.jhep.2010.07.032
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF HEPATOLOGY
• 影响因子: 25.7
• 作者: Kawaoka, Tomokazu;Hayes, C. Nelson;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B

• DOI: 10.1111/j.1872-034x.2011.00910.x
• 发表时间: 2012-02-01
• 期刊: HEPATOLOGY RESEARCH
• 影响因子: 4.2
• 作者: Matsumoto, Akihiro;Tanaka, Eiji;Kumada, Hiromitsu
• 通讯作者: Kumada, Hiromitsu

Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report

肝移植后丙型肝炎病毒基因型 1 感染复发患者从聚乙二醇干扰素 α-2b 转为 α-2a 和利巴韦林治疗后获得持续病毒缓解：病例报告

• DOI: 10.1159/000328661
• 发表时间: 2011
• 期刊: Intervirology (Elpub 25 Aug.)
• 作者: Kawaoka T;Hiraga N;Takahashi S;Takaki S;Tsuge M;Nagaoki Y;Hashimoto Y;Katamura Y;Muki D;Hiramatsu A;Waki K;Imamura M;Kawakami Y;Aikata H;Ochi H;Tashiro H;Ohdan H;Chayama K
• 通讯作者: Chayama K

Cutaneous complications after transcatheter arterial treatment for hepat ocellular carcinoma via the internal mammary artery : how to avoid this complication

经乳内动脉经导管动脉治疗肝眼细胞癌后的皮肤并发症：如何避免这种并发症

• DOI: 10.1007/s11604-011-0559-9
• 发表时间: 2011
• 期刊: Jpn J Radiol
• 影响因子: 2.1
• 作者: Kajiwara K;Kakizawa H;Takeuchi N;Toyota N;Hieda M;Ishikawa M;Tanitame K;Tani G;Suzuki T;Fujikawa K;Aikata H;Chayama K;Awai K
• 通讯作者: Awai K

治療方針のコンセンサス

治疗政策共识

• 发表时间: 2009
• 作者: 茶山一彰;今村道雄;高橋祥一
• 通讯作者: 高橋祥一