The role of IRF transcription factor family in inflammation-associated tumorigenesis

IRF转录因子家族在炎症相关肿瘤发生中的作用

• 批准号: 21390089
• 负责人: TAMURA Tomohiko
• 金额: $ 11.81万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390089/
• 关键词: 転写因子; 癌; 免疫学; 遺伝子; 細胞・組織; 発現制御

A role for chronic inflammation in tumorigenesis is now generally accepted, and nuclear factorκ-B(NF-κB) has been implicated in the cause or exacerbation of inflammation-induced cancers. The present study demonstrates that the interferon regulatory factor(IRF) transcription factor family, which can be activated simultaneously with NF-κB by innate immune stimuli, possesses tumor-suppressing abilities in inflammation-induced cancers.

现在普遍接受慢性感染在肿瘤发生中的作用，并且在感染引起的癌症的原因或加剧中，核因子κ-B（NF-κB）已被隐含。本研究表明，可以通过先天免疫刺激与NF-κB同时激活的干扰素调节因子（IRF）转录因子家族具有感染引起的癌症的肿瘤抑制能力。

项目成果

A shared role of transcription factors IRF4 and IRF8 in myeloid cell development

转录因子 IRF4 和 IRF8 在骨髓细胞发育中的共同作用

• 发表时间: 2009
• 作者: 加藤隆幸;ら
• 通讯作者: ら

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene

• DOI: 10.1073/pnas.0905702106
• 发表时间: 2009-07-28
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Nakajima, Akira;Nishimura, Keishiro;Tamura, Tomohiko
• 通讯作者: Tamura, Tomohiko

IRF8 transcription factor directs microglia to be a hyperactive phenotype driving neuropathic pain

IRF8转录因子引导小胶质细胞成为驱动神经性疼痛的过度活跃表型

• 发表时间: 2011
• 作者: Masuda T;Tsuda M;Yoshinaga R;Tozaki-Saitoh H;Tamura T;Inoue K
• 通讯作者: Inoue K

Interferon stimulation causes diverse changes in chromatin to regulate transcription

干扰素刺激导致染色质发生多种变化以调节转录

• 发表时间: 2011
• 作者: Ozato K;Sarai N;Patel M;Debrosse M;Tamura T;Ura K
• 通讯作者: Ura K

Regulation of immunity and oncogenesis by the IRF transcription factor family

• DOI: 10.1007/s00262-009-0804-6
• 发表时间: 2010-04-01
• 期刊: CANCER IMMUNOLOGY IMMUNOTHERAPY
• 影响因子: 5.8
• 作者: Savitsky, David;Tamura, Tomohiko;Taniguchi, Tadatsugu
• 通讯作者: Taniguchi, Tadatsugu