Functional analyses of receptor tyrosine kinases, Ror1 and Ror2, in Wnt signalin

Wnt 信号蛋白中受体酪氨酸激酶 Ror1 和 Ror2 的功能分析

• 批准号: 21390080
• 负责人: MINAMI Yasuhiro
• 金额: $ 11.98万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390080/
• 关键词: Wnt5a; Ror1; Ror2; 癌の浸潤; 神経細胞分化; Wntシグナル; MMP; 神経幹細胞性維持; Dishevelled; Wntシグナル伝達; チロシンキナーゼ; マトリックスメタロプロテアーゼ

In mammals, including humans, binding of an secreted protein, Wnt5a, to its cognate receptors, the receptor tyrosine kinases, Ror1 and Ror2, elicits intracellular signalings that play important roles in the morphogenesis of tissues and organs during the developmental processes. In this study, we have shown that Wnt5a-Ror1/Wnt5a-Ror2 signalings play important roles in the morphogenesis of tissues and organs by regulating cell polarity and migration, and have elucidated the relationship between abnormalities in these signalings and developmental anomalies and cancer invasion.

在包括人类在内的哺乳动物中，分泌的蛋白质Wnt5a与其同源受体的结合，受体酪氨酸激酶，ROR1和ROR2，在发育过程中会在组织和器官的形态发生中起重要作用，从而在发育过程中起着重要作用。在这项研究中，我们表明Wnt5a-Ror1/Wnt5a-Ror2信号通过调节细胞极性和迁移来在组织和器官的形态发生中起重要作用，并阐明了这些信号异常，发育异常和发育界异常之间的关系。

项目成果

疾患モデルとしての細胞種・組織特異的Ror2ノックアウトマウス

细胞类型/组织特异性 Ror2 敲除小鼠作为疾病模型

• 发表时间: 2011

Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity

• DOI: 10.1016/j.tripleo.2008.08.018
• 发表时间: 2009-03-01
• 期刊: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
• 作者: Kobayashi, Masaki;Shibuya, Yasuyuki;Komori, Takahide
• 通讯作者: Komori, Takahide

Non-canonical Wnt signaling and its relationship with human diseases

非经典Wnt信号传导及其与人类疾病的关系

• 发表时间: 2009
• 作者: Sakakida;Y.;大西 伸幸;南康博;南康博
• 通讯作者: 南康博

Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.

• DOI: 10.1016/j.devcel.2011.01.001
• 发表时间: 2011-02-15
• 期刊: DEVELOPMENTAL CELL
• 影响因子: 11.8
• 作者: Gao, Bo;Song, Hai;Bishop, Kevin;Elliot, Gene;Garrett, Lisa;English, Milton A.;Andre, Philipp;Robinson, James;Sood, Raman;Minami, Yasuhiro;Economides, Aris N.;Yang, Yingzi
• 通讯作者: Yang, Yingzi

Mice Lacking the Orphan Receptor Ror1 Have Distinct Skeletal Abnormalities and Are Growth Retarded

• DOI: 10.1002/dvdy.22362
• 发表时间: 2010-08-01
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Lyashenko, Natalia;Weissenboeck, Martina;Hartmann, Christine
• 通讯作者: Hartmann, Christine