Novel strategy for prediction of toxicity and efficacy of chemotherapy for patients with metastatic colorectal cancer.

预测转移性结直肠癌患者化疗毒性和疗效的新策略。

• 批准号: 21591725
• 负责人: HAZAMA Shoichi
• 金额: $ 2.91万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591725/
• 关键词: イリノテカン; セツキシマブ; UGT1A1; KRAS; BRAF; PI3K; Irinotecan; UGT1As; Cetuximab; cetuximab; P13K; EGFR; 遺伝子多型; 大腸癌; 化学療法

1. The toxicity of irinotecan, G3/ 4 neutropenia, was predicted by UGT1A1^* 28/^* 6 alleles as well as UGT1A7 N129K(G),-57(G), UGT1A9^* 22 alleles. Genotype subset selection of multi-UGT1As polymorphisms can predict severe neutropenia and tumor responses of metastatic CRC patients received FOLFIRI regimen.2. Mutations such as BRAF, and PI3K were also important biomarkers of cetuximab. Furthermore, our date suggest that the FcGR3_a polymorphisms may be also useful molecular markers to predict clinical outcome in mCRC pts treated with cetuximab.

1。伊立替康的毒性，G3/ 4中性粒细胞减少，由UGT1A1^* 28/^* 6等位基因以及UGT1A7 N129K（G），-57（g），UGT1A9^* 22 22等位基因预测。多态性多态性的基因型子集选择可以预测转移性CRC患者的严重中性粒细胞减少症和肿瘤反应接受了FOLFIRI方案。2。诸如BRAF和PI3K之类的突变也是西妥昔单抗的重要生物标志物。此外，我们的日期表明，FCGR3_A多态性也可能是有用的分子标记物，可以预测用西妥昔单抗治疗的MCRC PT中的临床结果。

项目成果

Possible involvement of Wnt11 in colorectal cancer progression

• DOI: 10.1002/mc.21845
• 发表时间: 2013-03-01
• 期刊: MOLECULAR CARCINOGENESIS
• 影响因子: 4.6
• 作者: Nishioka, Mitsuaki;Ueno, Koji;Hinoda, Yuji
• 通讯作者: Hinoda, Yuji

Prospective Phase II Study of FOLFIRI for mCRC in Japan, Including the Analysis of UGT1A1*28/*6 Polymorphisms

• DOI: 10.1093/jjco/hyr001
• 发表时间: 2011-04-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Okuyama, Yusuke;Hazama, Shoichi;Mishima, Hideyuki
• 通讯作者: Mishima, Hideyuki

Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells.

frizzled-7 表达的下调会降低结肠癌细胞的存活、侵袭和转移能力。

• DOI: 10.1038/sj.bjc.6605307
• 发表时间: 2009-10-20
• 期刊: British journal of cancer
• 影响因子: 8.8

Impact of chemotherapy for colorectal cancer on regulatory T-cells and tumor immunity

结直肠癌化疗对调节性 T 细胞和肿瘤免疫的影响

• 发表时间: 2011
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Maeda K;Hazama S;Tokuno K;Kan S;Maeda Y;Watanabe Y;Kamei R;Shindo Y;Maeda N;Yoshimura K;Yoshino S;Oka M
• 通讯作者: Oka M

Importance and practice of UGT1A1 polymorphisms

UGT1A1多态性的重要性和实践

• 发表时间: 2011
• 期刊: Nihon Rinsho
• 作者: Hazama S;Oka M
• 通讯作者: Oka M