3D analysis of regional hepatic blood flow by means of hepatic imaging using monochromatic synchrotron radiation

使用单色同步辐射通过肝脏成像对区域肝脏血流进行 3D 分析

• 批准号: 21591583
• 负责人: ITO Katsuyoshi
• 金额: $ 2.83万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591583/
• 关键词: エックス線・CT; 肝血流イメージング; 単色放射光; 肝血流; イメージング; 門脈血流; 門脈血液

3D analysis of regional hepatic blood flow was performed by means of hepatic flow imaging using monochromatic synchrotron radiation. Our results showed that micro-CT enables the evaluation of microanastomosis between small arteries and portal veins as well as the degree of neovascularization. This fact may help elucidate the cause of early enhancing hepatic pseudolesions observed in contrast-enhanced dynamic CT or MRI. Intrahepatic distribution of Gd-EOB-DTPA as a hepatocyte-specific contrast agent was also assessed by using normal and NASH model mouse. In normal mouse, predominant uptake of Gd-EOB-DTPA in the hepatocyte was observed. In NASH model mouse, uptake of Gd-EOB-DTPA gradually decreased, according to the progression of hepatic fibrosis, suggesting the relationship between hepatocyte function and dynamic changes of hepatic blood flow. Regarding the Gd deposition in the liver, Gd deposition in renal dysfunction model rat was minimal. However, Gd deposition was increased in hepatorenal dysfunction model rat, indicating the increased risk of deterioration of liver function.

使用单色同步加速器辐射通过肝流成像进行区域肝血流的3D分析。我们的结果表明，Micro-CT能够评估小动脉和门静脉之间的微型施法以及新血管形成程度。这一事实可能有助于阐明在对比增强动态CT或MRI中观察到的早期增强肝假期的原因。还通过使用正常和NASH模型小鼠评估了GD-EOB-DTPA作为肝细胞特异性对比剂的肝内分布。在正常小鼠中，观察到肝细胞中GD-EOB-DTPA的主要摄取。在NASH模型小鼠中，根据肝纤维化的进展，GD-EOB-DTPA的摄取逐渐减少，这表明肝细胞功能与肝血流的动态变化之间的关系。关于肝脏中的GD沉积，肾功能障碍模型大鼠中的GD沉积很小。但是，肝功能障碍模型大鼠中GD沉积增加，表明肝功能恶化的风险增加。

项目成果

「肝血流動態イメージと病理・病態」(4)肝硬変

“肝脏血流动力学图像和病理/状况”（4）肝硬化

• 发表时间: 2009
• 作者: Tamada T;Ito K;伊東克能
• 通讯作者: 伊東克能