Intermittent hypoxia in the progression of diabetic nephropathy and Intermittent hypoxia in the progression of diabetic nephropathy and Role of fatty acid binding protein

糖尿病肾病进展中的间歇性缺氧 糖尿病肾病进展中的间歇性缺氧及脂肪酸结合蛋白的作用

• 批准号: 21591043
• 负责人: KIMURA Kenjiro
• 金额: $ 2.91万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591043/
• 关键词: 間欠的低酸素; 虚血ストレス; 脂肪酸結合蛋白; 低酸素; 高血圧; 糖尿病; マウス; 間欠的虚血ストレス; 腎臓; 糖尿病性腎症; 尿蛋白; AKITA糖尿病マウス; 間質尿細管障害; 尿中アルブミン; 虚血; 実験動物

Because sleep apnea syndrome(SAS) may contribute to poor control of diabetes or hypertension, it is possible that SAS is a risk factor for the progression of diabetic nephropathy. In this study, genetic models of type 1 diabetes or hypertension model were examined. The mice or rats were housed within a cycled oxygen chamber and were exposed to chronic intermittent hypoxia(CIH) in which oxygen and nitrogen flow rates were adjusted to achieve episodic(10 miniute) reductions of ambient oxygen from 21% to 10% for CIH for 12 hours. Howerver, it was not demonstrated that chronic intermittent hypoxia was related to the deterioration of kidney disease induced by diabetes or hypertension.

由于睡眠呼吸暂停综合征（SAS）可能导致糖尿病或高血压控制不佳，因此 SAS 可能是糖尿病肾病进展的危险因素。在这项研究中，检查了 1 型糖尿病或高血压模型的遗传模型。将小鼠或大鼠安置在循环氧室内，并暴露于慢性间歇性缺氧（CIH）中，其中调整氧气和氮气流量，以实现 CIH 的环境氧气间歇性（10 分钟）从 21% 减少至 10%。 12小时。然而，尚无证据表明慢性间歇性缺氧与糖尿病或高血压引起的肾脏疾病恶化有关。