Regulation of immune dynamics by Rap1-RAPL-Mst1 signaling

Rap1-RAPL-Mst1 信号传导调节免疫动态

• 批准号: 21570207
• 负责人: KATAGIRI Koko
• 金额: $ 3.16万
• 依托单位: Kwansei Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570207/
• 关键词: Rap1; RAPL; adhesion; autoimmunity; p27; インテグリン; 遊走; 接着; 小胞輸送; Mst1; GTPase; ケモカイン; リン酸化; 低分子G蛋白質

RAPL, Rap1 binding protein, plays crucial roles in Rap1-dependent lymphocyte adhesion and migration. RAPL-deficient mice experienced age-related lupus-like glomerulonephritis and developed B cell lymphomas. RAPL promoted the nuclear localization of p27, cdk2 inhibitor, and prevented the hyperproliferation of both T and B lymphocytes induced by the crosslinking with the antibody to antigen receptors. These data demonstrated that lymphocyte adhesion and proliferation were coordinately regulated by RAPL, and the deficiency of such molecule solely led to the development of lymphoproliferative diseases.

Rapl，Rap1结合蛋白，在RAP1依赖性淋巴细胞粘附和迁移中起着至关重要的作用。 Rapl缺陷的小鼠经历了与年龄相关的狼疮样肾小球肾炎，并发展出B细胞淋巴瘤。 RAPL促进了P27，CDK2抑制剂的核定位，并防止了与抗原受体抗体交联引起的T和B淋巴细胞的过度增殖。这些数据表明，淋巴细胞粘附和增殖受RAPL协调调节，这种分子的缺乏仅导致淋巴增生性疾病的发展。

项目成果

Deficiency of Rap1-GTP binding protein RAPL causes lymphoproliferative disorders through the mislocalization of cyclin-dependent kinase inhibitor p27^<kip1>.

Rap1-GTP 结合蛋白 RAPL 的缺陷通过细胞周期蛋白依赖性激酶抑制剂 p27^<kip1> 的错误定位导致淋巴增殖性疾病。

• 发表时间: 2011
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Katagiri K;Ueda Y;Tomiyama T;Yasuda K;Toda Y;Ikehara S;Nakayama I. K and Kinashi T;平岡泰;Katagiri K.
• 通讯作者: Katagiri K.

Deficiency of Rap1 binding protein RAPL causes lymphoproliferative disorders through the mislocalization of p27^<kip1>

Rap1 结合蛋白 RAPL 的缺陷通过 p27^<kip1> 的错误定位导致淋巴增殖性疾病

• 发表时间: 2011
• 作者: Katagiri K.;et. al.
• 通讯作者: et. al.

Deficiency of Rap1-GTP binding protein RAPL causes lymphoproliferative disorders through the mislocalization of cyclin-dependent kinase inhibitor p27^<kip1>

Rap1-GTP 结合蛋白 RAPL 的缺陷通过细胞周期蛋白依赖性激酶抑制剂 p27^<kip1> 的错误定位导致淋巴增殖性疾病

• 发表时间: 2011
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Katagiri K;Ueda Y;Tomiyama T;Yasuda K;Toda Y;Ikehara S;Nakayama I. K and Kinashi T
• 通讯作者: Nakayama I. K and Kinashi T

Deficiency of RAPL causes lymphoproliferative disorders through the mislocalization of p27^<kip1>

RAPL 缺陷通过 p27^<kip1> 的错误定位导致淋巴增殖性疾病

• 发表时间: 2011
• 作者: Katagiri K.;et. al.
• 通讯作者: et. al.

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

• DOI: 10.1038/emboj.2009.82
• 发表时间: 2009-05-06
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Katagiri, Koko;Katakai, Tomoya;Kinashi, Tatsuo
• 通讯作者: Kinashi, Tatsuo