Satellite cell activation to the change of muscle fiber size and the effects of motor nerve innervations and aging

卫星细胞激活对肌纤维尺寸变化以及运动神经支配和衰老的影响

• 批准号: 21500633
• 负责人: OISHI Yasuharu
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500633/
• 关键词: 熱ストレス; 再生筋線維; 衛星細胞; ミオシン重鎖; ヒラメ筋; ラット; 速筋線維; 遅筋線維; heat shock protein; 筋線維組成; 速筋型ミオシン重鎖; 遅筋型ミオシン重鎖; Myo D

Analyses were performed on the fiber phenotype expression, satellite cell activation, and the effects of heat stress at an early stage of rat soleus fiber regeneration. In heat stressed soleus regenerating fibers, slow type fiber containing only the slow myosin heavy chain isoform and enhanced activation of satellite cells were observed. These results suggest the possibility that heat stress accelerates the shift of fiber phenotype from fast to slow at an early stage of soleus fiber regenerating process.

在大鼠纤维再生的早期阶段对纤维表型表达，卫星细胞活化以及热应激的影响进行了分析。在热应力的比目鱼再生纤维中，仅观察到较慢的纤维纤维，仅含有缓慢的肌球蛋白重链同工型，并观察到卫星细胞的激活增强。这些结果表明，在比目鱼纤维再生过程的早期阶段，热应力会加速纤维表型从快速变为速度。

项目成果

絶食に伴う筋委縮に対する代償性過負荷の影響

代偿性超负荷对禁食相关肌肉萎缩的影响

• 发表时间: 2011
• 作者: 緒方知徳;大石康晴
• 通讯作者: 大石康晴

Differential cell death regulation between adult-unloaded and aged rat soleus muscle

• DOI: 10.1016/j.mad.2009.02.001
• 发表时间: 2009-05-01
• 期刊: MECHANISMS OF AGEING AND DEVELOPMENT
• 影响因子: 5.3
• 作者: Ogata, Tomonori;Machida, Shuichi;Muraoka, Isao
• 通讯作者: Muraoka, Isao

Muscle Cell Physiology. Edt. Section 5 : Calcineurin signaling pathways in mammalian skeletal muscles

肌肉细胞生理学。

• 发表时间: 2009
• 作者: Oishi Y;et al.;Yasuharu Oishi
• 通讯作者: Yasuharu Oishi

「Muscle Cell Physiology」Section 5 : Calcineurin

《肌肉细胞生理学》第五节：钙调神经磷酸酶

• 发表时间: 2009
• 作者: Oishi Y;et al.;Yasuharu Oishi;Oishi Yasuharu
• 通讯作者: Oishi Yasuharu

Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers

• DOI: 10.1152/japplphysiol.91651.2008
• 发表时间: 2009-11-01
• 期刊: JOURNAL OF APPLIED PHYSIOLOGY
• 影响因子: 3.3
• 作者: Oishi, Yasuharu;Hayashida, Mari;Ohira, Yoshinobu
• 通讯作者: Ohira, Yoshinobu