Analysis of mechanism in reducing pain during orthodontic tooth movement by CO_2 laser

CO_2激光减轻正畸牙移动疼痛的机制分析

• 批准号: 20592401
• 负责人: DEGUCHI Toru
• 金额: $ 3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592401/
• 关键词: 歯の移動; 神経ペプチド; レーザー; 三次元形態計測; C-fos蛋白; グリア細胞; アストロサイト; 骨細胞

The aim of this study is to investigate the pain reducing effect and mechanism of CO2 laser during orthodontic tooth movement. In the present study, we analyzed the effect of CO2 laser in the central (medullary dorsal horn)and in the peripheral (tooth pulp, periodontal ligament)nervous system during experimental tooth movement in rats. As a result, increased c-fos known as the pain marker, was observed after experimental tooth movement, and it significantly decreased at the medullary dorsal horn after CO2 laser irradiation. On the other hand, there was no significant change in the calcitonin gene-related peptide (CGRP)and PGP9. 5 at the tooth pulp and periodontal ligament after the irradiation of CO2 laser. Furthermore, by the temperature measurements, the maximum temperatures were less than 40°C, which cannot cause tissue injury. Therefore, it is suggested that the CO2 laser reduces pain during experimental tooth movement by inhibiting c-fos neurons at the central nervous system without damaging peripheral tissue.

本研究的目的是探讨 CO2 激光在正畸牙齿移动过程中的疼痛减轻效果和机制。在本研究中，我们分析了 CO2 激光在中央（髓背角）和周边（牙髓、牙髓）的效果。结果，在实验性牙齿移动后，观察到被称为疼痛标记的 c-fos 增加，并且在实验性牙齿移动后，其在髓质背角显着减少。另一方面，CO2激光照射后，牙髓和牙周膜处的降钙素基因相关肽（CGRP）和PGP9.5没有显着变化。最高温度低于40°C，不会造成组织损伤，因此，建议CO2激光通过抑制中枢神经系统的c-fos神经元来减轻实验性牙齿移动过程中的疼痛。损害周围组织。

项目成果

矯正用インプラントを固定源として上顎前歯の牽引を行った上顎前突症例

以正畸种植体为固定源，上颌前牙后缩的上颌前突病例。

• 发表时间: 2010
• 作者: 竹下信郎;福本恵美子;出口徹;高橋一郎;山本照子
• 通讯作者: 山本照子

CO2レーザーの疼痛軽減効果に関する研究. 実験的歯の移動における三叉神経脊髄路核のFos蛋白の発現

CO2激光实验性牙齿移动过程中三叉神经脊髓束核Fos蛋白表达的研究

• 发表时间: 2008
• 作者: Seiryu M;Deguchi T;Fujiyama K;Sakai Y;Daimaruya T;Takano-Yamamoto T
• 通讯作者: Takano-Yamamoto T

側貌骨格形態と顎運動機能の関連性について

关于侧方骨骼形态与下颌运动功能的关系

• 发表时间: 2008
• 作者: Kataoka T;Hashimoto T;Deguchi T;Shiraga N;Imai M;Minato M;Takano-Yamamoto T;Yamashiro T
• 通讯作者: Yamashiro T

Histomorphometric Evaluation of Cortical Bone Thickness Surrounding Miniscrew for Orthodontic Anchorage

• DOI: 10.1111/j.1708-8208.2009.00197.x
• 发表时间: 2011-01-01
• 期刊: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
• 影响因子: 3.6
• 作者: Deguchi, Toru;Yabuuchi, Toshinori;Takano-Yamamoto, Teruko
• 通讯作者: Takano-Yamamoto, Teruko

Histomorphometric evaluation of alveolar bone turnover between the maxilla and the mandible during experimental tooth movement in dogs

• DOI: 10.1016/j.ajodo.2006.12.013
• 发表时间: 2008-06-01
• 期刊: AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
• 影响因子: 3
• 作者: Deguchi, Toru;Takano-Yamamoto, Teruko;Garetto, Lawrence P.
• 通讯作者: Garetto, Lawrence P.