The effects of adiponectin on lung cancer and lung disease

脂联素对肺癌和肺部疾病的影响

• 批准号: 20591674
• 负责人: TSUCHIYA Tomoshi
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591674/
• 关键词: アディポネクチン; リポポリサッカライド; 小胞体ストレス; 肺気腫; 肺癌; マイクロアレイ

In order to find out the effect of adiponectin on lung cancer and lung disease, we made elastase inhalation model, VEGF receptor blocker model, and LPS administration model. However obvious inhivitive effects were not observed. In the subcutaneous lung cancer cell injection model, the regular diet group of Tg mice showed increase tumor size and weight. Because the size of adipocytes were small and mRNA expressions of p21 and p16 and protein expressions of p21 and p53 were suppressed in adipose tissue of Tg mice, we presume the tissues of Tg mice are kept homeostasis in "young", which might induce cancer growth in adipose tissue.

为了找出脂联素对肺癌和肺部疾病的影响，我们制作了弹性酶吸入模型，VEGF受体阻滞剂模型和LPS给药模型。但是，未观察到明显的不传动作用。在皮下肺癌细胞注射模型中，常规的TG小鼠饮食组显示出增加肿瘤的大小和体重。由于脂肪细胞的大小很小，并且p21和p16的mRNA表达以及p21和p53的蛋白质表达在TG小鼠的脂肪组织中抑制，因此我们认为TG小鼠的组织在“ Young”中保持稳态，这可能会诱导脂肪组织中的癌症生长。

项目成果

Overexpression of adiponectin is in involved in suppression of cell cycle regulators/senescence-related signals in adipose tissue

脂联素的过度表达参与抑制脂肪组织中的细胞周期调节因子/衰老相关信号

• 发表时间: 2011
• 作者: Shoji T;Bando T;Fujinaga T;Okubo K;Yukawa N;Mimori T;Date H.;Ryotaro Kamohara
• 通讯作者: Ryotaro Kamohara

Overexpression of regulators/ senescence-related signals in adipose tissue

脂肪组织中调节因子/衰老相关信号的过度表达

• 发表时间: 2011
• 作者: 蒲原涼太郎;下川功
• 通讯作者: 下川功