Inactivation of DNA repair gene and their associations with development and progression of pancreatic cancer

DNA修复基因失活及其与胰腺癌发生发展的关系

• 批准号: 20591619
• 负责人: SUZUKI Hideki
• 金额: $ 2.58万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591619/
• 关键词: pancreatic cancer; DNA repair gene; H2AX; MSH2; ATM; 膵臓癌; DNA修復遺伝子

We already reported that DNA double-strand break(s) (DSBs) repair are related to chromosomal deletions / aberrations. And this result suggested that aberrations of DSBs repair are reflected to some parts of tumorgenesis and developments in pancreatic cancer. In this study, we examined that the relationship of tumorgenesis in pancreatic cancer and aberrations of DSB repair genes. At first, we selected three DSBs repair genes, H2AX, MSH2 and ATM, and examined amount of expressions of these genes at surgical specimens. At the same time, we examined localizations of these genes at surgical specimens. At last, we will compare some clinical or pathological information and the expressions of these genes (on going).

我们已经报道过 DNA 双链断裂 (DSB) 修复与染色体缺失/畸变有关。这一结果表明，DSBs修复的异常反映在胰腺癌肿瘤发生和发展的某些部分。在这项研究中，我们研究了胰腺癌肿瘤发生与 DSB 修复基因畸变的关系。首先，我们选择了三个DSB修复基因H2AX、MSH2和ATM，并检查了这些基因在手术标本中的表达量。与此同时，我们检查了这些基因在手术标本中的定位。最后，我们将比较一些临床或病理信息以及这些基因的表达（正在进行）。

项目成果

Diagnostic usefulness of FDG-PET for malignant somatostatinoma of the pancreas.

• 发表时间: 2008-07
• 期刊: Hepato-gastroenterology
• 作者: Hideki Suzuki;H. Kuwano;N. Masuda;S. Hashimoto;K. Kanoh;K. Nomoto;T. Shimura;H. Katoh

Laparoscopic partial liver resection for hepatocellular carcinoma in liver cirrhosis.

腹腔镜肝部分切除术治疗肝硬化肝细胞癌。

• 发表时间: 2008
• 期刊: Hepatogastroenterology 55(88)
• 作者: 武冨紹信;杉町圭史;武石一樹;戸島剛男;森田和豊;池上徹;山下洋市;祇園智信;副島雄二;前原喜彦;Suzuki H. KuwanoH. Masuda N. et al.;Suzuki H. Shimura T. Suehiro T. Araki K.et al.
• 通讯作者: Suzuki H. Shimura T. Suehiro T. Araki K.et al.

Nuclear beta-catenin expression at the invasive front and in the vessels predicts liver metastasis in colorectal carcinoma.

• 发表时间: 2008
• 期刊: Anticancer research
• 影响因子: 2
• 作者: Hideki Suzuki;N. Masuda;T. Shimura;K. Araki;Tsutomu Kobayashi;S. Tsutsumi;T. Asao;H. Kuwano