Development of Porphyrinoid Materials Aimed at Non-linear Optics and Photodynamic Therapy
用于非线性光学和光动力治疗的类卟啉材料的开发
基本信息
- 批准号:20850004
- 负责人:
- 金额:$ 2.1万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (Start-up)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Synthesis of novel porphyrinoids aimed at development of nonlinear optical materials or photodynamic therapy medicines had been started. At first, since unpredictable synthetic problems were found during the synthesis of oligo-pyrrole precursors according to the reported procedure, the reaction conditions were modified so that formation of byproducts was suppressed. In addition, a rare oligo-pyrrole unit bearing a pyridine ring that was difficult to introduce so far was synthesized. The target β-alkyl substituted hexaphyrin (1.1.1.1.1.1) was seemed to be unstable in free base and neutral state, so reproducibility of the reaction was very low and characterization had been carried out only in the protonated form to date. This time, the synthetic method was revised and the reaction intermediate was isolated before oxidized. As aresult, the final step of the purification was dramatically simplified and reproducibility of the reaction was raised. Furthermore, the quick working up made it possible to measure ^1H NMR spectrum of the neutral state of hexaphyrin. This observation revealed that two inner meso-protons of neutral hexaphyrin was pointing inward of the macrocycle in the similar maaner to the protonated form. Moreover, zinc complex of the hexaphyrin was more stable than the free base. This complex showed strong aromaticity and optical property analogous to porphyrin. This is the first example that maintains the inherent aromaticity of the parent molecule among zinc complexes of hexaphyrins (1.1.1.1.1.1) or general metalcomplexes of meso-free hexaphyrins (1.1.1.1.1.1). Good single crystals of the zinc complex suitable for X-ray analysis were obtained, but coordination with the other metals was not achieved. On the other hand, unique bis-BF_2 and bis-Rh(CO)_2 complexes of non-conjugated macrocyclic bis-dipyrrin units were synthesized using the isolated intermediate.
为了开发非线性光学材料或光动力治疗药物,已经开始合成新型卟啉类化合物。首先,由于在按照报道的方法合成低聚吡咯前体过程中发现了不可预测的合成问题,因此修改了反应条件,以便形成。此外,还合成了迄今为止难以引入的带有吡啶环的稀有低聚吡咯单元。 (1.1.1.1.1.1)在游离碱和中性状态下似乎不稳定,因此反应的重现性非常低,迄今为止仅以质子化形式进行了表征。中间体反应在氧化前被分离,因此纯化的最终步骤得到了显着简化,反应的重现性也得到了提高。此外,快速的后处理使得测量 1H NMR 谱成为可能。该观察表明,中性六菲瑞的两个内部介观质子以与质子化形式类似的方式指向大环内部,而且六菲瑞的锌配合物比游离碱表现出更强的稳定性。类似于卟啉的芳香性和光学性质这是第一个在六菲林锌配合物中保持母体分子固有芳香性的例子。 (1.1.1.1.1.1)或不含内消旋六菲啉的一般金属络合物(1.1.1.1.1.1)获得了适合X射线分析的良好的锌络合物单晶,但未实现与其他金属的配位。另一方面,使用分离的非共轭大环双联吡啶单元合成了独特的双-BF_2和双-Rh(CO)_2配合物中间的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Application of the Perimeter Model to the Assignment of the Electronic Absorption Spectra of Gold(III)Hexaphyrins with[4n+2]and[4n]π-Electron Systems
周长模型在[4n+2]和[4n]π-电子体系金(III)六菲林电子吸收光谱归属中的应用
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:A.Muranaka;O.Matsushita;K.Yoshida;S.Mori;M.Suzuki;T.Furuyama;M.Uchiyama;A.Osuka;N.Kobayashi
- 通讯作者:N.Kobayashi
メゾフリーヘキサフィリン (1.1.1.1.1.1) の合成と物性
游离内消旋六菲林的合成和物理性质(1.1.1.1.1.1)
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:小出太郎;柏崎玄伍;鈴木優章;古川貢;大須賀篤弘
- 通讯作者:大須賀篤弘
ヘムタンパク質の電子構造を解明するためのメソ13Cプローブ : ミオグロビンケース
用于阐明血红素蛋白电子结构的 Meso-13C 探针:肌红蛋白案例
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:池崎章;根矢三郎;鈴木優章;星野忠次;中村幹夫
- 通讯作者:中村幹夫
HIV-1逆転写酵素RNase H活性阻害薬の設計と合成
HIV-1逆转录酶RNase H活性抑制剂的设计与合成
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:細谷亮裕;鈴木優章;星野忠次;根矢三郎;細谷亮裕;大地貴之;松ケ枝隆;京都;藤秀義;久冨喜弘;松元輝礁
- 通讯作者:松元輝礁
炭素13で特異標識したポルフィリンの合成とヘムタンパク質NMRへの応用
碳13特异性标记卟啉的合成及其在血红素蛋白核磁共振中的应用
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:根矢三郎;鈴木優章;星野忠次;池崎章;中村幹夫
- 通讯作者:中村幹夫
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SUZUKI Masaaki其他文献
TAKANO-YAMAMOTO Teruko Japanese men OSAHS patient's anatomical features
TAKANO-YAMAMOTO Teruko 日本男性 OSAHS 患者的解剖特征
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
OKUBO Mau;SUZUKI Masaaki - 通讯作者:
SUZUKI Masaaki
SUZUKI Masaaki的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SUZUKI Masaaki', 18)}}的其他基金
Development of PET probes of neuroprotective molecular components in oriental medicines
韩方神经保护分子成分PET探针的研制
- 批准号:
25242070 - 财政年份:2013
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of three-dimensional pi-electronic compounds originated from tripyrrin subunits
源自三吡啉亚基的三维π电子化合物的开发
- 批准号:
24750034 - 财政年份:2012
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
On epimorphisms between knot groups non-preserving meridians
论结群不守经脉间的同态
- 批准号:
24740035 - 财政年份:2012
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development and exploration of expanded porphyrins bearing intramolecular conjugation bridges
具有分子内共轭桥的扩展卟啉的开发与探索
- 批准号:
22750031 - 财政年份:2010
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
A Study on the faithfulness of the graded Magnus representation of the mapping class group
映射类群分级马格努斯表示的忠实度研究
- 批准号:
21740033 - 财政年份:2009
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of Nitrogen Isotope Separation Method using Plasma Chemical Reactions
利用等离子体化学反应开发氮同位素分离方法
- 批准号:
19360424 - 财政年份:2007
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Relations of depositional processes on coastal and alluvial plains formation and the Late Holocene climate change
沿海和冲积平原形成的沉积过程与全新世晚期气候变化的关系
- 批准号:
18500784 - 财政年份:2006
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Three-dimensional morphological analyses of positional dependence in patients with obstructive sleep apnea syndrome
阻塞性睡眠呼吸暂停综合征患者位置依赖的三维形态学分析
- 批准号:
17591802 - 财政年份:2005
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Radio-Active Waste Decontamination Process by Using Atmospheric Pressure Plasma and Its Safety Analysis.
常压等离子体放射性废物净化工艺开发及其安全性分析。
- 批准号:
13558060 - 财政年份:2001
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Novel PET Tracers for Prostaglandin Receptors
前列腺素受体的新型 PET 示踪剂
- 批准号:
11694143 - 财政年份:1999
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Synthetic challenge to creation of spiro-aromatic expanded porphyrinoids
螺芳香族扩张型卟啉类化合物的合成挑战
- 批准号:
22K05081 - 财政年份:2022
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
ヘキサフィリンを主とした新規環拡張ポルフィリンの合成とその応用
新型扩环卟啉(主要是六卟啉)的合成及其应用
- 批准号:
20J20954 - 财政年份:2020
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Development of pseudo-aromatic systems consisting of cyclic resonance and multiple hydrogen bonding
由循环共振和多重氢键组成的拟芳香体系的开发
- 批准号:
18K05082 - 财政年份:2018
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
新規反芳香族ポルフィリノイドの創出
新型抗芳香族卟啉类化合物的制备
- 批准号:
17J10262 - 财政年份:2017
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Development of three-dimensional spiro-aromatic systems
三维螺芳香系统的开发
- 批准号:
15K05419 - 财政年份:2015
- 资助金额:
$ 2.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)