Investigation of roles of DSCAM in mental retardation of Down syndrome

DSCAM在唐氏综合症智力低下中的作用研究

• 批准号: 20790758
• 负责人: AMANO Kenji
• 金额: $ 2.66万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790758/
• 关键词: ダウン症候群; 精神遅滞; Ts1Cje; DSCAM; TslCje; Ts1CjeDSCAM; 動試験; マウスモデル; トリソミー; 過剰発現

Ts1Cje, a mouse model of Down syndrome, shows several abnormal phenotypes including decreased body weight, deficient spatial memory in Y-maze task, and enlarged brain ventricles that might relate to the mental retardation of Down syndrome. I compared these phenotypes between Ts1Cje and Ts1Cje-Dscam(+/+/-) mice to investigate the roles of DSCAM, but the phenotypes were not improved in Ts1Cje-Dscam(+/+/-) mice. These results suggest that the overexpression of DSCAM does not lead to these phenotypes in Ts1Cje mice.

TS1CJE是唐氏综合症的小鼠模型，显示了几种异常表型，包括体重减轻，Y迷宫任务中的空间记忆不足以及可能与唐氏综合症的精神障碍有关的大脑心室的增大。我比较了TS1CJE和TS1CJE-DSCAM（+/+/ - ）小鼠之间的这些表型，以研究DSCAM的作用，但在TS1CJE-DSCAM（+/+/ - ）小鼠中没有改善表型。这些结果表明，DSCAM的过表达不会导致TS1CJE小鼠的这些表型。