Role of renin-angiotensin system on atherosclerotic plaque rupture

肾素-血管紧张素系统在动脉粥样硬化斑块破裂中的作用

• 批准号: 20790532
• 负责人: SUZUKI Jun
• 金额: $ 2.75万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790532/
• 关键词: 分子血管病態学; 動脈硬化; プラーク破碇; アンジオテンシン; マクロファージ; 酸化ストレス; プラーク破綻

The incidence of plaque rupture was significantly reduced in Apolipoprotein E (ApoE)/Angiotensin II type 1a receptor (AT_<1a>R) double knockout mice compared with ApoE knockout mice. Lipid accumulation, macrophage infiltration into the plaque, superoxide anion production, and matrix metalloproteinase activity were markedly attenuated in ApoE/AT_<1a>R knockout mice compared with ApoE knockout mice. These findings suggest that AT_<1a>R blocking could decrease the incidence of atherosclerotic plaque rupture, and that AT_<1a>R mediated inflammation, oxidative stress, and MMP activation may have an important role in plaque vulnerability.

与ApoE敲除小鼠相比，载脂蛋白E(ApoE)/血管紧张素II 1a型受体(AT_1aR)双敲除小鼠中斑块破裂的发生率显着降低。与ApoE敲除小鼠相比，ApoE/AT_1aR敲除小鼠中的脂质积累、巨噬细胞渗入斑块、超氧阴离子产生和基质金属蛋白酶活性显着减弱。这些发现表明AT_ 1a R阻断可以降低动脉粥样硬化斑块破裂的发生率，并且AT_ 1a R介导的炎症、氧化应激和MMP活化可能在斑块脆弱性中具有重要作用。

项目成果

Angiotensin II Type 1a Receptor Deficiency Attenuates Atherosclerotic Plaque Rupture

血管紧张素 II 1a 型受体缺陷可减轻动脉粥样硬化斑块破裂

• 发表时间: 2010
• 作者: 青野潤;鈴木純;他
• 通讯作者: 他