The measurement and the evaluation of chromogranin A in saliva as an objective index of the mental stress in psychosomatic disease

唾液中嗜铬粒蛋白A作为心身疾病精神应激客观指标的测定与评价

• 批准号: 12670434
• 负责人: SUZUKI Jun
• 金额: $ 0.77万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670434/
• 关键词: chromogranin A; psychosomatic disease; depression; panic disorder; white coat hypertension; stress related diseases; 唾液中ストレスマーカー; chromogranin A; ストレス; 白衣高血圧; 自律神経機能; 抑うつ状態; 唾液中human chromogranin A; 精神的ストレス; 数値逆唱ストレス負荷

Objective : It is generally thought that the factor of the external stress and the difference of sensitivity to the stress influence greatly on the occurrence and the progress in psychosomatic disease. In this regards, to estimate psychosomatic response quantitatively to the stress, we measured the concentration of chromogranin A in saliva. Methods : The 14 normal volunteers were requested to keep the rest condition for 30 minutes, then they received mental stress for 3 minutes. We measured the concentration of chromogranin A in saliva at 3 time points before, during and after the stress. Results : When-the stress was loaded, the concentration of chromogranin A in saliva (0.80±0.19 pmol/ml) increased significantly (p<0.05) compared with the concentration before the stress (0.32±0.08 pmol/ml). On the other hand, the concentrations of chromogranin A of outpatients who visited our hospital were measured. The concentrations of patients with depression (1.02±0.93 pmol/ml), those with panic disorder (1.56±1.78 pmol/ml), and those with white coat hypertension (8.97±6.50 pmol/ml), were all higher significantly than that of the normal volunteers (0.32±0.28 pmol/ml). Conclusions : These data suggested that the concentration of the chromogranin A in saliva increased transiently by the burden of the stress, and it might be a good quantitative index of the patients with psychosomatic disease.

目的：一般认为外界应激的因素以及对应激的敏感性差异对心身疾病的发生和进展影响较大，为此，为了定量地估计心身对应激的反应，我们测量了浓度。方法：让14名正常志愿者保持休息状态30分钟，然后接受精神应激3分钟，测量前3个时间点唾液中嗜铬粒蛋白A的浓度。结果：当施加压力时，唾液中嗜铬粒蛋白 A 的浓度 (0.80±0.19 pmol/ml) 与压力之前的浓度 (0.32±0.08 pmol/ml) 相比显着增加 (p<0.05)。另一方面，测定了就诊于本院的门诊患者的嗜铬粒蛋白A浓度（1.02±0.93）。 pmol/ml）、惊恐障碍组（1.56±1.78 pmol/ml）、白大衣高血压组（8.97±6.50 pmol/ml）均显着高于正常志愿者（0.32±0.28 pmol/ml）结论：这些数据表明，唾液中嗜铬粒蛋白A的浓度因压力负担而短暂升高，这可能是心身疾病患者的一个良好的定量指标。疾病。

项目成果

鈴木順, 星野健, 井上洋西 他: "精神的ストレスの客観的指標としての唾液中クロモグラニンA濃度測定"Jpn.J Psychosom Med. 41(4). 297-297 (2001)

Jun Suzuki、Ken Hoshino、Hironishi Inoue 等人：“唾液嗜铬粒蛋白 A 浓度的测量作为心理压力的客观指标”Jpn.J Psychosom Med 41(4) (2001)。

Suzuki Jun, Hoshino Ken, Inoue Hiroshi: "The measurement of human chromogranin A in saliva as an objective index of the mental stress"Jpn J Psychosom Med, 41 Suppl. 103 (2001)

铃木淳，星野健，井上宏：“唾液中人类嗜铬粒蛋白A的测量作为精神压力的客观指标”Jpn J Psychosom Med，41 Suppl。

Suzuki Jun, Hoshino Ken, Inoue Hiroshi: "The measurement of chromogranin A in saliva as an objective index of the mental stress"Jpn J Psychosom Med, 41(4). 297 (2001)

铃木淳，星野健，井上宏：“唾液中嗜铬粒蛋白A的测量作为精神压力的客观指标”Jpn J Psychosom Med，41（4）。

鈴木順, 星野健, 井上洋西 他: "ストレス関連疾患における唾液中クロモグラニンA濃度の検討"Jpn.J Psychosom Med. 43(10)(印刷中). (2003)

Jun Suzuki、Ken Hoshino、Yonishi Inoue 等：“压力相关疾病中唾液嗜铬粒蛋白 A 浓度的研究”Jpn.J Psychosom Med 43(10)（出版中）。

鈴木 順: "精神的ストレスの客観的指標としての唾液中ヒトクロモグラニンA濃度測定"Jpn J Psychosom Med. 41Supp.II. 103 (2001)

Jun Suzuki：“唾液中人嗜铬粒蛋白 A 浓度的测量作为心理压力的客观指标”Jpn J Psychosom Med 41Supp.II。