Functions of myeloid-lectin receptors

骨髓凝集素受体的功能

• 批准号: 20390109
• 负责人: INABA Kayo
• 金额: $ 12.65万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390109/
• 关键词: 動物; 細胞; 分子; 炎症; レクチン; マクロファージ; 樹状細胞; C型レクチン; 好中球; 肝炎; 表現型; 活性化; 細胞分化; 機能; 単球; リンパ器官; 皮膚

We generated SIGNR3-specific mAbs and investigated SIGNR3 expression in vivo. SIGNR3 was expressed on a vast majority of CD11b^+CD11c^<low> myeloid cells in various tissues, such as blood, dermis, lung, spleen and lymph nodes. By the cell transfer experiments using fluorescenated Ly6C^<high>SIGNR3^- bone marrow monocytes, SIGNR3 expression was upregulated along with the decrease in Ly6C expression during the circulation. Upon arrival at the peripheral LNs through HEV, the inoculated cells differentiated into CD11b^+ DCs in a couple of days. These results indicate that some DCs, especially in the subcutaneous lymph nodes, are possibly replenished by Ly6C^<high> monocytes.DCIR1 was detected mainly intracellularly in various cell types, but transferred onto the cell surface by the activation with LPS and TNF-α.

我们在体内产生了SIGNR3特异性mAb，并研究了在各种组织中的髓样细胞上的SIGNR3表达。 Signr3表达在循环中的ly6c表达中与ly6c的表达相关。主要在各种细胞类型中检测到细胞内，但通过LPS和TNF-α的激活转移到细胞表面上。

项目成果

Ly49Q plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.

Ly49Q 通过调节筏运输在中性粒细胞极化和迁移中发挥至关重要的作用。

• 发表时间: 2010
• 期刊: Immunity 32
• 作者: Sasazuki T(8番目);Toyama-Sorimachi N(10番目:全10名)
• 通讯作者: Toyama-Sorimachi N(10番目:全10名)

Role of SIGNR1 mocleuls in innate immune responses

SIGNR1 分子在先天免疫反应中的作用

• 发表时间: 2010
• 作者: J.Arii;H.Goto;T.Suenaga;M.Oyama;H.Kozuka-Hata;T.Imai;A.Minowa;H.Akashi;H.Arase;Y.Kawaoka;Y.Kawaguchi.;Kayo Inaba
• 通讯作者: Kayo Inaba

Rho-mDial pathway is required for adhesion, migration, and T cell stimulation in dendritic cells.

Rho-mDial 通路是树突状细胞粘附、迁移和 T 细胞刺激所必需的。

• 发表时间: 2010
• 期刊: Blood 116(26)
• 作者: Tanizaki;H.;Egawa;G.;Inaba;K.;Honda;T.;Nakajima;S.;Sagita Moniaga;C.;Otsuka;A.;Ishizaki;T.;Tomura;M.;Watanabe;T.;Miyachi;Y.;Narumiya;S.;Okada;T.;Kabashima;K.
• 通讯作者: K.

Regulation of B cell function and development through IRF-2 in type I interferon receptor-dependent and-independent mechanisms

IRF-2 在 I 型干扰素受体依赖性和非依赖性机制中调节 B 细胞功能和发育

• 发表时间: 2010
• 作者: Mi-ichi F.;Abu Y.M.;Nakada-Tsukui K.;Kawai S.;Nozaki T.;Wakayama Y;Kento Minamino
• 通讯作者: Kento Minamino

Binding property of SIGNR1 against surface mannoproteins of Candia albicans

SIGNR1 对白色念珠菌表面甘露糖蛋白的结合特性

• 发表时间: 2010
• 作者: Matsubayashi J;Takanashi M;Oikawa K;Mingli Xu;Mukai K;Kuroda M;Mukai K;Sumika Tokieda
• 通讯作者: Sumika Tokieda