Research and development of bioactive marine natural products

生物活性海洋天然产物的研究与开发

• 批准号: 20390001
• 负责人: KOBAYASHI Jun'ichi
• 金额: $ 12.65万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390001/
• 关键词: 機能性天然分子; 海洋天然物; 分子標的; 天然物ライブラリー; 海洋生物

Investigation of extracts of an Okinawan marine organisms (sponge, tunicate, and dinoflagellate etc.) resulted in the isolation of new manzamine alkaloids exhibiting antimalarial and antitrypanosomal activities, new pyridinium alkaloids exhibiting acetylcholine esterase inhibitory activity, and new terpenoid quinones exhibiting tyrosine kinase inhibitory activity. In addition, many new compounds that show cytotoxic activity (pyridine alkaloids, beta-carboline alkaloids, bromotyrosine alkaloids, a macrolide, and sesquiterpenoids) and anti-microbial activity (bromopyrrole alkaloids, bromotyrosine alkaloids, triterpenoids) were isolated from the marine organisms. The absolute stereochemistries of known cytotoxic macrolides, previously isolated from dinoflagellete by our group, were also elucidated.

Investigation of extracts of an Okinawan marine organisms (sponge, tunicate, and dinoflagellate etc.) resulted in the isolation of new manzamine alkaloids exhibiting antimalarial and antitrypanosomal activities, new pyridinium alkaloids exhibiting acetylcholine esterase inhibitory activity, and new terpenoid quinones exhibiting tyrosine kinase inhibitory activity 。此外，许多新的化合物都显示出细胞毒性活性（吡啶碱，β-钙化碱生物碱，溴苯酪氨酸生物碱，大环内酯类和倍半萜类化合物）和抗微生物活性（溴吡咯碱基，溴洛氏菌属菌种，wareserys syripers syripers syripers syripers syripers syripers syripers syripers syripers syripers）还阐明了我们组以前从鞭lag虫分离的已知细胞毒性大环内酯类的绝对立体化体。

项目成果

アデノシン受容体に特異的に作用する機能性分子の探索

寻找特异性作用于腺苷受体的功能分子

• 发表时间: 2008
• 作者: T. Sezaki;K. Inada;T. Sogabe;K. Ueda;N. Kioka;小林淳一
• 通讯作者: 小林淳一

海綿 Xestospongia sp.由来の Xestoquinone 関連化合物の構造

海绵 Xestospongia sp 中 Xestoquinone 相关化合物的结构。

• 发表时间: 2008
• 作者: Katsumi H;et al.;Masahito Ochiai;宇野公之;今祐司
• 通讯作者: 今祐司

Chemistry and biology of bioactive natural products from marine and other sources

海洋和其他来源的生物活性天然产物的化学和生物学

• 发表时间: 2008
• 作者: M.Ohiai;T.Okada;N.Tada;A.Yoshimura;小林淳一
• 通讯作者: 小林淳一

The Mukaiyama Aldol and Mukaiyama-Michael Reaction Promoted by Commercially Available Molecular Sieves

市售分子筛促进的 Mukaiyama Aldol 和 Mukaiyama-Michael 反应

• DOI: 10.3987/com-09-s
• 发表时间: 2010
• 期刊: Heterocycles
• 影响因子: 0.6
• 作者: Anada;M.; Washio;T.; Watanabe;Y.; Hashimoto;S.
• 通讯作者: S.

Halichonadins G-J, new sesquiterpenoids from a sponge Halichondria sp.

Halichonadins G-J，来自海绵 Halichondria sp. 的新倍半萜类化合物。

• DOI: 10.1016/j.tetlet.2011.04.105
• 发表时间: 2011
• 期刊: Tetrahedron Lett.
• 作者: Suto;S.; Tanaka;N.; Fromont;J.; Kobayashi;J.
• 通讯作者: J.