Research for utilization of unused natural resources

未利用自然资源的利用研究

• 批准号: 11793014
• 负责人: KOBAYASHI Jun'ichi
• 金额: $ 8.64万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for University and Society Collaboration
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11793014/
• 关键词: symbiotic dinoflagellate; drug discovery; supplement; plants of northern districts; marine organism; marine microorganism; 共渦鞭毛藻; Amphidinium; マクロリド; 絶対立体配置; 殺細胞活性; 生合成; エゾユズリハ; 日本産イチイ; 健康補助食品; 生活習慣病; 北海道; ハイイヌガヤ; アルカロイド

1) A new anthracycline-derived pentacyclic metabolite, seragakinone A, and new peptides, dictyonamides A and B, were isolated from a marine-derived fungus Cocodinium sp., and the structures were determined on the basis of combination of NMR analyses, X-ray analysis, and degradation experiments. Seragakinone A showed antimicrobial activity, while dictyonamide A exhibited inhibitory activity against CDK-4.2) Three new lycopodium alkaloids, seratezomines A 〜 C, with seco-seratinine-type, a seratenine-type, and a lycodoline-type skeletons, respectively, were isolated from the club moss Lycopodium serratum var. serratum. On the other hand, three new alkaloids, complanadine A, lyconadine A, 11-hydroxy lycodine, were isolated from lycopodium complanatum.3) Fifteen new Daphniphyllum alkaloids, daphnezomines A 〜 G and daphnicyclidins A 〜 H were isolated from Daphniphyllum humile and D. teijsmanni. Daphnezomines A and B are novel alkaloids with aza-adamantane core, while daphnezomines F and G have a 1-azaobicyclo[5.2.2]undecene ring system. Daphnicyclidins A 〜 H possess unque fused hexa- or pentacyclic skeletons.4) Three new bicyclic peptides, celogentins A 〜 C, were isolated together with moroidin from the seeds of Celosia argentea. Celogentins A 〜 C and moroidin inhibited the polymerization of tubulin. Structure-activity relationship study using four moroidin derivatives as well as Celogentins A 〜 C and moroidin indicated that the bicyclic ring system including non-peptide connections among β^S-Leu, Trp, and His residues with ring size and conformations suitable for interaction with tubulin would be important for their activity.

1）新的邻苯二酚代谢产物，塞拉吉金A和新肽，dictynamides a和b s cocodinium sp。以及基于NMR分析，X-雷分析和降解实验的组合确定结构A显示了抗菌活性CDK-4.2）三个新的乳杆菌生物碱A〜C，具有seco-seratine-type，血清氨酸型和氨基二氨基型骨骼，尊敬的氨基氨基骨骼A，11-羟基柠檬氨酸是从羊脂中分离出来的。3）15个新的dachniphyllum balkaloids，daphnezomines a〜g g和dachnicleclidins a〜h re与humile and humile and d. aza-adamantane core a a a za-adamantane fatne a a〜h re。 1-azaobicyclo [5.2.2] dachniclclidins a〜h具有未列出的hexa-或五囊骨架。4）三个新的自行车肽，celogentins a〜c celogentins a〜c celosia a celosia a〜c and celogentea a〜c c celogentea a〜c c celogentina a〜c c and Moroidea。遗传性抑制素。使用四个摩洛定素衍生物以及celogentins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludins ncludin and trp和他的居民之间具有大小和构型的居民之间的替代性，适合与小管蛋白相互作用。

项目成果

H. Morita, et al.: "Serratezomines A〜C, New Alkaloids from Lycopodium serratum var. serratum"J. Org. Chem.. 65. 6241-6245 (2000)

H. Morita 等：“Serratezomines A~C，来自石松 var. serratum 的新生物碱” J. Org. 65. 6241-6245 (2000)

H.Morita: "Daphnezomines A and B, novel alkaloids with an aza-adamantane core from Daphniphyllum humile"J. Org. Chem.. 64. 7208-7212 (1999)

H.Morita：“Daphnezomines A 和 B，来自 Daphniphyllum humile 的具有氮杂金刚烷核心的新型生物碱”J.

H.Morita: "Daphnezomines H,I,J,and K,new daphnilactone-type alkaloids from Daphniphyllum humile"Tetrahedron. 56. 2641-2646 (2000)

H.Morita：“Daphnezomines H、I、J 和 K，来自 Daphniphyllum humile 的新瑞香内酯型生物碱”四面体。

H. Morita, et al.: "Senepodine A, a novel C_<22>N_2 alkaloid from Lycopodium chinens"Tetrahedron Lett.. 42. 4199-4201 (2001)

H. Morita等人：“Senepodine A，一种来自石松的新型C_ 22 N_2生物碱”Tetrahedron Lett.. 42. 4199-4201 (2001)

M. Sekiguchi, et al.: "Pacovatinins A〜C, new labdane diterpenoids from the seeds of Renealmia exaltata"J. Nat. Ptod.. 64. 1102-1106 (2001)

M. Sekiguchi 等人：“Pacovatinins A~C，来自 Renealmia exaltata 种子的新 Labdane 二萜” J. Nat. 64. 1102-1106 (2001)