The Mechanism Underlying the Formation of Activity-Dependent Thalamocortical Projection

活动依赖性丘脑皮质投射形成的机制

• 批准号: 20300110
• 负责人: YAMAMOTO Nobuhiko
• 金额: $ 12.65万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300110/
• 关键词: 軸索分岐; 軸索誘導; 神経活動; 層特異性; 視床; 大脳; HDAC9; 遺伝子発現調節; c-fos; 樹状突起; 核細胞質移動; 軸索; 同期性; Kir2.1; 軸索分枝; RhoA; 神経回路

Neural activity is well known to play an important role in neural circuit formation. However, the mechanism is largely unknown. We studied the role of neural activity in axonal branch formation, focusing on the thalamocortical projection in the mammalian brain. The result shows that both activities of growing thalamic axons (presynaptic) and their target cortical neurons (postsynaptic) promote axon branching. Evidence also suggests the underlying molecular mechanisms.

众所周知，神经活动在神经回路的形成中发挥着重要作用。然而，其机制很大程度上是未知的。我们研究了神经活动在轴突分支形成中的作用，重点关注哺乳动物大脑中的丘脑皮质投射。结果表明，生长中的丘脑轴突（突触前）及其目标皮质神经元（突触后）的活动都会促进轴突分支。证据还表明了潜在的分子机制。

项目成果

Molecular Mechanisms of Oriented Axon Growth of Cortical Projection Neurons.

皮质投射神经元定向轴突生长的分子机制。

• 发表时间: 2009
• 作者: 諏訪牧子;小野幸輝;杉原稔;Yamamoto N.
• 通讯作者: Yamamoto N.

Pre-and post synaptic cell firing history regulates branch formation in thalamocortical.

突触前和突触后细胞放电历史调节丘脑皮质的分支形成。

• 发表时间: 2008
• 作者: Yamamoto N;Hayashi A;Yamada A;Uesaka N;Hayano Y
• 通讯作者: Hayano Y

The role of pre-and post-synaptic cell activity in thalamocortical axon branching.

突触前和突触后细胞活动在丘脑皮质轴突分支中的作用。

• 发表时间: 2008
• 作者: Yamamoto N;Yamada A;Hayano Y;Uesaka N
• 通讯作者: Uesaka N

Single cell electroporation method for axon tracing in cultured slices.

用于培养切片中轴突示踪的单细胞电穿孔方法。

• 发表时间: 2008
• 期刊: Dev Growth Differ 50
• 作者: Uesaka N;Nishiwaki M;Yamamoto N
• 通讯作者: Yamamoto N

A molecular mechanism that regulates callosal axon growth.

调节胼胝体轴突生长的分子机制。

• 发表时间: 2008
• 作者: Zhao H;Maruyama T;Shirasaki R;Yamamoto N
• 通讯作者: Yamamoto N