Development and Application of Methods for Catalytic Asymmetric Synthesis of Planar-Chiral Metallocene Complexes

平面手性茂金属配合物催化不对称合成方法的开发及应用

• 批准号: 20200051
• 负责人: OGASAWARA Masamichi
• 金额: $ 19.14万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200051/
• 关键词: メタロセン; 不斉合成; 面不斉; 均一系触媒; 有機金属錯体; 遷移金属触媒; 光学活性; メタセシス

As shown in various planar-chiral metallocenylphosphine ligands, transition-metal complexes with planar chirality are useful chiral templates and have been utilized in asymmetric synthesis as chiral catalysts and chiral reagents. In spite of their usefulness, catalytic asymmetric reactions of preparing such planar-chiral compounds have bee extremely rare. In this research project, we have succeeded to develop various novel protocols of catalytically preparing planar-chiral metallocene derivatives in high enantiomeric purity. The methods we have developed include kinetic resolution of racemic planar-chiral metallocenes as well as asymmetric desymmetrization of planar-prochiral phosphaferrocenes. We have also demonstrated that our methods can be applicable to kinetic resolution of planar-chiral (η^6-arene)chromium complexes, indicating potential versatility of the protocols.

项目成果

Enantioselective Synthesis of Planar-Chiral Phosphaferrocenes by Molybdenum-Catalyzed Asymmetric Interannular Ring-Closing Metathesis

• DOI: 10.1021/ja910348z
• 发表时间: 2010-02-24
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Ogasawara, Masamichi;Watanabe, Susumu;Takahashi, Tamotsu
• 通讯作者: Takahashi, Tamotsu

Transition-Metal-Catalyzed Enantioselective Synthesis of Compounds with Non-Centrochirality

• DOI: 10.1055/s-0029-1216818
• 发表时间: 2009-06-03
• 期刊: SYNTHESIS-STUTTGART
• 影响因子: 2.6
• 作者: Ogasawara, Masamichi;Watanabe, Susumu
• 通讯作者: Watanabe, Susumu

Pd-Catalyzed Asymmetric Synthesis of Unfunctionalized Axially Chiral Allenic Hydrocarbons by Desulfonylation Approach : Total Synthesis of Extract from Australian Melolonthine Scarab Beetles

钯催化去磺酰化方法不对称合成非功能化轴向手性烯丙烃：澳大利亚金龟子提取物的全合成

• 发表时间: 2009
• 作者: Michio Tajima;Atsushi Ogura;他;Tatsuhiro Numata;小笠原正道
• 通讯作者: 小笠原正道

面不斉メタロセンの触媒的不斉合成と光学活性メタロセン・ポリマー合成への応用

平面手性茂金属的催化不对称合成及其在光学活性茂金属聚合物合成中的应用

• 发表时间: 2008
• 作者: Ogasawara;M;小笠原 正道;小笠原 正道;小笠原正道
• 通讯作者: 小笠原正道

Transition-Metal-Catalyzed Enantioselective Synthesis of Planar-Chiral Transition-Metal Complexes

过渡金属催化平面手性过渡金属配合物的对映选择性合成

• 发表时间: 2009
• 作者: 小笠原 正道;小笠原 正道;宮地 太一;小笠原正道;小笠原正道
• 通讯作者: 小笠原正道