Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

鉴定与健康和长寿相关的新型营养信号：在预防常见疾病中的作用。

• 批准号: 19680030
• 负责人: TAKETANI Yutaka
• 金额: $ 10.32万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19680030/
• 关键词: シグナル伝達; リン; 血管内皮細胞; 高リン血症; 心血管疾患; 慢性腎臓病; 予防栄養学; 血管内皮機能; 血管内皮

Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.

营养物质及其代谢物在足够水平的水平内保持平衡，以维持正常的生理功能。不利饮食对营养代谢平衡的损害会导致生活方式相关疾病，例如糖尿病，心血管疾病等。在这项研究中，我们研究了营养信号的作用，尤其是针对“磷酸盐信号”的作用，尤其是在衰老和某些相关疾病上密切相关的“磷酸盐信号”。高磷酸盐摄入引起的高磷酸血症可以通过磷酸盐信号诱导内皮功能障碍，这将是心血管clise骨的危险因素。

项目成果

Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases.

低血糖指数和低磷饮食对糖尿病肾病和衰老相关疾病的优势。

• 发表时间: 2007
• 期刊: J Med Invest 54
• 作者: Taketani Y;Shuto E;Nishida Y;Tanaka R.
• 通讯作者: Tanaka R.

Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction.

餐后高磷酸盐血症是涉及内皮功能障碍的心血管疾病的新危险因素。

• 发表时间: 2008
• 作者: Shuto E;Taketani Y;Tanaka R;Tanimura A;Uebanso T;Isshiki M;Harada N;Yamamoto H;Nakaya Y;Takeda E.
• 通讯作者: Takeda E.

Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia.

III 型钠依赖性磷酸转运蛋白在高磷血症引起的动脉硬化发病机制中的双重作用。

• 发表时间: 2009
• 作者: Faustino;J.B.;Sumida;M.;Fajardo;A.C.;Pawilen.;G.T;Yutaka Taketani
• 通讯作者: Yutaka Taketani

Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production.

血清磷升高对内皮功能的急性影响与氧化应激和 NO 产生有关。

• 发表时间: 2009
• 作者: Taketani Y;Shuto E;Shiota A;Watari E;Kitamura T;HaradaN;Nakaya Y;Miyamoto K;Takeda E.
• 通讯作者: Takeda E.

Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats.

血清磷水平的波动损害大鼠的内皮功能。

• 发表时间: 2009
• 作者: Eriko Watari;Tormoyo Kitamura;Yutaka Taketani;Ayako Tanimura;Asuka Shiota;Enai Shuto;Tan Vu Van;Hironori Yamamoto;Eiji Takeda
• 通讯作者: Eiji Takeda