Mechanism of initiation and development of cerebral aneurysm : Using cerebral aneurysm model

脑动脉瘤发生和发展的机制：使用脑动脉瘤模型

基本信息

批准号：
19591705
负责人：
KASUYA Hidetoshi
金额：
$ 2.91万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2009
项目状态：
已结题

项目摘要

The purpose of this study is to establish cerebral aneurysm model in dogs for the study of initiation and development of cerebral aneurysm. Cerebral aneurysms were induced by the treatment of ligation of the common carotid and renal artery, experimental hypertension and β-aminopropionitrile feeding using eleven dogs. Cerebral angiography was performed every three months till 15 months. One animal in the treated group show saccular cerebral aneurysm visualized by cerebral angiography at basilar bifurcation at three months and gradually developed. Histologically, the aneurysm wall was very thin deposited with fibrinoid, internal elastic lamina became thinner and had splits, and number of smooth muscle cells decreased with disturbed arrangement. Thus, this cerebral aneurysm model is similar to that of human. We would like to continue this work for efficiently producing cerebral aneurysm model in large animal.

这项研究的目的是在狗中建立脑动脉瘤模型，以研究脑动脉瘤的启动和发育。通过使用十一只狗的结扎，实验性高血压和β-氨基丙二硫化剂喂养来诱导大脑动脉瘤。每三个月至15个月进行一次脑血管造影。治疗组中的一只动物显示，在三个月后基底分叉时，通过脑血管造影可视化的寒冷脑动脉瘤，并逐渐发展。从组织学上讲，动脉瘤壁非常薄，用纤维蛋白素沉积，内部弹性薄片变细并分裂，平滑肌细胞的数量随着排列的干扰而减少。这是这种脑动脉瘤模型类似于人类的模型。我们想继续这项工作，以有效地在大动物中产生脑动脉瘤模型。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Identification of susceptibility loci for intracranial aneurysm Ident ification of susceptibility loci for intracranial aneurysm

颅内动脉瘤易感位点的识别颅内动脉瘤易感位点的识别

DOI：
发表时间：
2008
期刊：
Nature Genet 40
影响因子：
0
作者：
Bilguvar K;Yasuno K;Niemela M;… Kasuya H;et al
通讯作者：
et al

Follow-up of large aneurysms treated with coil embolization at an acute stage in patients with poor-grade subarachnoid hemorrhage.

对严重蛛网膜下腔出血患者急性期采用弹簧圈栓塞治疗的大动脉瘤进行随访。

DOI：
发表时间：
2009
期刊：
Interventional Neuroradiology 15
影响因子：
0
作者：
Hagiwara S;Tanaka N;Tani S;Nakamura S;Ohbuchi H;Hirota K;Iwabuchi S;Kasuya H
通讯作者：
Kasuya H

Characterization of functional and quality of life in patients following SAH with and without nicardipine prolonged release pellets J

使用和不使用尼卡地平缓释颗粒的 SAH 患者功能和生活质量的特征 J