Application of glycolytic metabolic images by positron emission tomography to the qualitative diagnosis of digestive organ cancers and the evaluation of chemotherapeutic effects.

正电子发射断层扫描糖酵解代谢图像在消化器官肿瘤定性诊断及化疗效果评估中的应用

基本信息

批准号：
10670820
负责人：
YOSHIOKA Takashi
金额：
$ 1.34万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

The development of positron emission tomography (PET) has made it possible to study directly tissue metabolism. Fluorine-18-2-deoxy-D-glucose (FDG), a structual analog like glucose, is a PET tracer for the glycolytic process. Because increased glycolysis is one of the most important characteristics of cancer cells, FDG-PET has been used to image successfully various kinds of human neoplasms.Firstly, basic studies were carried out for the application of FDG-PET tumor images to the field of the digestive cancer chemotherapy, using human cancer transplantable into nude mice. When FDG tumor uptake were compared with histology, FDG uptake increased with loss of differentiation. When influence of chemotherapy on FDG was examined, FDG uptake decreased in parallel to the efficacy of anticancer agents and administrated doses of agents and correlated with subsequent morphologic changes. These results suggested that FDG-PET tumor images was useful for the qualitative diagnosis of cancers and the … More evaluation of chemotherapeutic effects.Secondly, clinical FDG-PET studies were carried out. The sensitivity of the gastric cancer detection by FDG-PET tumor image was 84% on the study of 25 gastric cancer patients. The correlation of FDG uptake values and prognosis was not shown on the study of 16 pancreatic cancer patients. However, these studies were small number of patients and further investigation were warranted.In the period of this study, two important cases followed by FDG-PET during chemotherapy were experienced. The first case was a patient with abdominal lymph node metastases from colon cancer followed by CT and FDG-PET.FDG-PET tumor images changed in accordance with clinical progress, whereas CT findings relatively unchanged. The second case was a patient with multiple liver and mediastinal lymph node metastases. FDG-PET had detected mediastinal lymph node metastases since the start of chemotherapy, but CT had missed them throuout the clinical course and they were clarified by the autopsy. These cases showed that FDG-PET tumor image was suitable for follow-up after chemotherapy. We hope the collection of the cases like these. Less

正电子发射断层扫描 (PET) 的发展使得直接研究组织代谢成为可能，氟-18-2-脱氧-D-葡萄糖 (FDG) 是一种与葡萄糖类似的结构，是糖酵解过程增加的 PET 示踪剂。糖酵解是癌细胞最重要的特征之一，FDG-PET已成功用于多种人类肿瘤的成像。 FDG-PET肿瘤成像到消化道癌症化疗领域，使用可移植到裸鼠的人类癌症当FDG肿瘤摄取与组织学比较时，FDG摄取随着分化的丧失而增加当检查化疗对FDG的影响时，FDG摄取。这些结果表明，FDG-PET 肿瘤图像可用于癌症的定性诊断和评估。其次，进行了临床FDG-PET研究，在25名胃癌患者的研究中，FDG-PET肿瘤图像检测胃癌的敏感性为84%。对 16 名胰腺癌患者的研究并未显示预后，但这些研究的患者数量较少，有必要进一步研究。在本研究期间，对两个重要病例进行了 FDG-PET 随访。第一个病例是一位结肠癌腹部淋巴结转移的患者，随后进行了 CT 和 FDG-PET 检查。FDG-PET 肿瘤图像随着临床进展而变化，而 CT 表现相对不变。患有多发性肝脏和纵隔淋巴结转移的患者，自化疗开始以来，FDG-PET 已检测到纵隔淋巴结转移，但 CT 在整个临床过程中漏掉了这些转移，并通过尸检得以澄清。表明FDG-PET肿瘤影像适合化疗后随访，希望此类病例少一些。