The relationship between the gene expression profile and the type of hearing impairment.

基因表达谱与听力障碍类型之间的关系。

• 批准号: 19791202
• 负责人: SUZUKI Nobuyoshi
• 金额: $ 2.28万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791202/
• 关键词: 高音障害型難聴; 老人性難聴; 遺伝子発現パターン; SAM; レーザーマイクロダイセクション; 高音障害型感音難聴; SAMマウス

Many hearing impairments are known to be caused by genetic factor. Heareditary hearing loss contributes to the various type of hearing impairments. However, little is known about what lead to such many different phenotypes. And now, it is generally accepted that the importance of the searching another responsible genes for auditory disturbance or the identification with the localization of transcription products. We hypothesized that the variety of phenotypes are caused by not only distribution of products but also the differences in the pattern of the gene expression. We attempted to identify the gene expression analysis in the cochlea by using Real-Time PCR with laser micro dissection system and the DNA microarray analysis with using the model mouse for age-related hearing impairment.

众所周知，许多听力障碍是由遗传因素引起的。听觉性听力损失会导致各种类型的听力障碍。然而，人们对于是什么导致如此多不同的表型知之甚少。现在，人们普遍认为寻找另一种听觉障碍相关基因或识别转录产物的定位的重要性。我们假设表型的多样性不仅是由产物的分布引起的，而且是由基因表达模式的差异引起的。我们尝试通过使用带有激光显微解剖系统的实时PCR和使用年龄相关性听力障碍模型小鼠的DNA微阵列分析来鉴定耳蜗中的基因表达分析。

项目成果

SAMP1の内耳における遺伝子発現について

SAMP1在内耳中的基因表达

• 发表时间: 2008
• 作者: 上條篤;他;鈴木伸嘉
• 通讯作者: 鈴木伸嘉

Gene expression profiles in the cochlea of the senscence-accelerated mouse(SAM)

感知加速小鼠（SAM）耳蜗中的基因表达谱

• 发表时间: 2007
• 作者: 鈴木伸嘉;橋本繁成;森政之;樋口京一;宇佐美真一;鈴木 伸嘉
• 通讯作者: 鈴木 伸嘉