A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors

胃肠道间质瘤分子靶向药物继发耐药机制研究

• 批准号: 19590410
• 负责人: HIROTA Seiichi
• 金额: $ 2.83万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590410/
• 关键词: 腫瘍; c-kit遺伝子; 機能獲得性突然変異; 分子標的治療; イマチニブ; 二次耐性; 付加変異; exon 13; exon 17; exon13; exon17

We first reported that an imatinib-secondary resistant lesion had secondary c-kit gene mutation in addition to primary c-kit gene mutation. Through analysis of many imatinib-secondary resistant lesions, 70 to 80% of them were proved to have secondary c-kit gene mutations in addition to primary c-kit gene mutations. Most of the secondary c-kit gene mutations were present at exon 13 or exon 17.

我们首先报道说，除了原代C-KIT基因突变外，伊马替尼抑制性病变还具有继发性C-KIT基因突变。通过分析许多伊马替尼二级抗性病变，事实证明，其中有70％至80％的抗性病变除了原代C-kit基因突变外，还具有继发性C-KIT基因突变。大多数次级C-KIT基因突变都存在于外显子13或外显子17。

项目成果

mouse model of human GIST

人类胃肠道间质瘤小鼠模型

• 发表时间: 2008
• 作者: S akamoto K;Sakurai S;Kanda T;Sakuma Y;Hishima T;Hironaka M;Bamba T;Keira Y;Takano Y;Niki T;Hasegawa T;Hirota S;Nishida T;Nishida T;Yamamoto S;Segawa E;Hirota S
• 通讯作者: Hirota S

Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells

胃肠道间质瘤模型细胞皮下肿瘤淋巴结转移模型的建立

• 发表时间: 2009
• 期刊: Oncol Rep 21
• 作者: S akurama K;Naomoto Y;Ohara T;Watanabe N;Takaoka M;Nagatsuka H;Tomono Y;Tanida T;Noma K;Tanabe S;Fujiwara Y;Motoki T;Shirakawa Y;Yamatsuji T;Hirota S;Taguchi T;Tanaka N
• 通讯作者: Tanaka N

Gastric leiomyosarcoma manifesting peculiar findings: Radiological-pathological correlation

• DOI: 10.1111/j.1440-1827.2009.02370.x
• 发表时间: 2009-05-01
• 期刊: PATHOLOGY INTERNATIONAL
• 影响因子: 2.2
• 作者: Masuzawa, Naoko;Kishimoto, Mitsuo;Yanagisawa, Akio
• 通讯作者: Yanagisawa, Akio

Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions

• DOI: 10.1053/j.gastro.2008.01.081
• 发表时间: 2008-05-01
• 期刊: GASTROENTEROLOGY
• 影响因子: 29.4
• 作者: Koma, Yu-Ichiro;Furuno, Tadahide;Ito, Akihk
• 通讯作者: Ito, Akihk

Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors

幼年胃肠道间质瘤中糖基化的异常表达

• 发表时间: 2008
• 期刊: Proteomics Clin Appl 2
• 作者: T akahashi T;Naka T;Fujimoto M;Serada S;Horino J;Terabe F;Hirota S;Miyoshi E;Hirai T;Nakajima K;Nishitani A;Souma Y;Sawa Y;Nishida T
• 通讯作者: Nishida T