The efficacy of biotin on the skin diseases related to dental Rats a

生物素对大鼠牙科相关皮肤病的疗效

基本信息

批准号：
18592202
负责人：
TAKAHASHI Shinichi
金额：
$ 2.24万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592202/
关键词：
pustulosis palmoplantaris biotin dental focus metal allergy IL-6 掌蹠膿疱症

项目摘要

We investigated 18 patients with pustular palmoplantaris (PPP) on the existence of osteoarthritis, periodontitis and the efficacy of biotin by scoring the severity of eruption with PPPASI (palmoplantar Pustular Psoriasis Area Severity Index). We also analyzed CD4/8 and plasma concentration of TNF-a , IL-6 and biotin before and after biotin treatment. Serum concentration of biotin was measured by competitive enzyme-linked assay.We found osteoarthritis (39%), periodontitis (56%) very frequently in these patients. However, these complications did not correlate with severity of eruptions. Elevations of plasma concentrations of IL-6 was detected in 4 of our patients, although there wasno significant. changes of CD4/8 and TNF-a . In these 4 cases three patients had severe periodontitis and one had pyelonephritisSerum concentration of biotin was about 100 times higher in the patients with administration of 9 or 12mg of biotin daily than those without biotin treatment. There was no significant difference of serum biotin concentration between patients with 9mg daily and those with 12mg daily. This result means 9mg of biotin per''day is enough for the treatment of the patients with PPP.Biotin was very effective for 14(78%)patients investigated. PPPASI of the patients was significantly lowered after biotin treatment (p<0.01). Biotin was also effective for the osteoarthritis. Serum IL-6 concentration was significantly decreased after biotin treatment (p<0.01). Furthermore, we confirmed synergic effect of dental treatment on eruptions and osteoarthritis of the patients with PPP.These results indicate IL-6 may be a useful marker for severe periodontitis in the patients with PPP. We also suggest biotin (9mg daily) together with dental treatment for periodontitis is quite effective for PPP.

我们通过PPPASI（掌跖脓疱性银屑病面积严重指数）对皮疹的严重程度进行评分，调查了18名掌跖脓疱型银屑病（PPP）患者是否存在骨关节炎、牙周炎以及生物素的疗效。我们还分析了生物素治疗前后的 CD4/8 以及 TNF-a、IL-6 和生物素的血浆浓度。通过竞争性酶联测定法测定血清生物素浓度。我们发现这些患者经常患有骨关节炎（39%）、牙周炎（56%）。然而，这些并发症与皮疹的严重程度无关。我们的 4 名患者中检测到血浆 IL-6 浓度升高，但并不显着。 CD4/8和TNF-a的变化。在这4例患者中，3名患者患有严重牙周炎，1名患者患有肾盂肾炎。每天服用9或12mg生物素的患者的血清生物素浓度比未治疗的患者高约100倍。每日9mg与每日12mg的患者血清生物素浓度无显着差异。这一结果意味着每天9毫克生物素足以治疗PPP患者。生物素对所调查的14名（78%）患者非常有效。生物素治疗后患者的 PPPASI 显着降低（p<0.01）。生物素对骨关节炎也有效。生物素处理后血清IL-6浓度显着降低（p<0.01）。此外，我们证实了牙科治疗对 PPP 患者出牙和骨关节炎的协同作用。这些结果表明 IL-6 可能是 PPP 患者严重牙周炎的有用标志物。我们还建议生物素（每天 9 毫克）与牙周炎牙科治疗相结合对 PPP 非常有效。