Objective measurement of patch test reactions due to dental metal compounds by measuring the erythema index and quantity of corneous moisture

通过测量红斑指数和角质水分含量来客观测量牙科金属化合物引起的斑贴试验反应

• 批准号: 16592021
• 负责人: TAKAHASHI Shinichi
• 金额: $ 0.7万
• 依托单位: Tokyo Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16592021/
• 关键词: dental metal allergy; patch test; eryhtema index; quantity of corneous moisture

Using the mice delayed hypersensitivity to dinitrochlorobenzene model, we compared the ear swelling rate with erythema index (E.I. ; measured with MEXAMETER MX18【○!R】) and quantity of corneous moisture (Q.G.M. ; measured with CORNEOMETER CM825【○!R】). The ear swelling rate showed a highly significant positive correlation with E.I. but not with Q.C.M. Therefore, E.I was employed for the objective assessment of patch test reactions.To establish the optimal method for this assessment, we measured the effects of measurement intervals and tape application on E.I. during the patch test reactions in normal volunteers. At the site of metal compound and tape application, E.I. was significantly higher within 30 min after tape removal than after >40 min. E.I. was significantly higher on the 2nd,3rd, and 7th day post-patch test than before the patch test. We concluded that to eliminate the effects of tape application on E.I. most effectively, the standard deviation value (S.D.V) of E.I. at the test site should be preferred over E.I. at the control sites (sites of adjacent tape application and the adjacent normal skin).We measured the S.D.V. of E.I. in patients with metal allergy (n=10), in those with an irritant reaction (n=10), and in the control group (n=10) on the 2nd,3rd, and 7th day post-patch test. The S.D.V. of E.I. was significantly higher in patients with metal allergy than in the control group on all days examined. S.D.V. was higher in patients with irritant reactions than in the control group on the 2nd and 3rd day, but not on the 7th day. Only on the 7th day, patients with metal allergy had a higher S.V.D. than those with an irritant reaction. These results suggested that patch test reactions can be objectively assessed with MEXAMETER by employing consecutive measurements.

使用小鼠延迟对Dinitrochorobenzene模型的高敏性，我们将耳朵肿胀率与红斑指数Mexameter MX18 [○！R]）和数量Q.C.C.的高度相关性。胶带和胶带的应用，tape tape> 40分钟后（S.D.V）在测试部位的E.I.应进行相邻的胶带和相邻的正常皮肤。在第2天和第七天金属的S.V.D。与那些枯萎的刺激性反应相比，可以通过使用连续的测量来客观地对其进行耕ath的茅草反应。

项目成果

歯科金属アレルギーにおける皮膚貼付試験判定の改善

牙科金属过敏皮肤斑贴试验判断的改进

• 发表时间: 2005
• 期刊: 日本口腔科学会雑誌 54・5
• 作者: 高田篤史;森本光明;山根源之;高橋愼一他
• 通讯作者: 高橋愼一他

皮膚科における扁平苔癬の診断と治療

皮肤科扁平苔藓的诊治

• 发表时间: 2004
• 期刊: 日本口腔粘膜学会雑誌 10
• 作者: 川島淳子;高橋愼一;両馬良樹;小俣裕昭 他1名;Hiroyuki Nakagawa;高橋愼一
• 通讯作者: 高橋愼一

亜鉛によるアレルギー性口内炎の診断におけるリンパ球幼若化試験の有用性について

关于淋巴细胞回春试验在诊断锌引起的过敏性口腔炎中的作用

• 发表时间: 2005
• 期刊: 日本口腔粘膜学会雑誌 11・1
• 作者: 岡村泰人;森本光明;山根源之;高橋愼一 他
• 通讯作者: 高橋愼一 他

Pyodermatitis-pyostomatitis vegetans

脓皮炎-植物性脓口炎

• 发表时间: 2005
• 期刊: 皮膚病診療 27・増
• 作者: 高橋愼一;川島淳子;森本光明;山根源之 他
• 通讯作者: 山根源之 他

再発性多発性軟骨炎の1例

复发性多软骨炎一例

• 发表时间: 2004
• 期刊: 日本臨床皮膚科医学会雑誌 80
• 作者: 川島淳子;高橋愼一
• 通讯作者: 高橋愼一