Disturbance of hepatic function and over nutrition-related diseases

肝功能障碍和过度营养相关疾病

• 批准号: 18109008
• 负责人: KANEKO Shuichi
• 金额: $ 64.4万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18109008/
• 关键词: ゲノム; 発現制御; 肝臓; 栄養; 生活習慣病; 糖尿病

Liver uptakes varieties of nutrients, metabolizes glucose, proteins, lipids, and drugs and systemically delivers the metabolites through blood streams. We have demonstrated that nutrition related diseases such as atherosclerosis, diabetes, cancer, and inflammation are partially caused by the dysfunction of liver which uptakes excess nutrients. We established the concept of the liver related diseases, and showed the fundamental findings for the development of the diagnosis and therapy for the diseased liver.

肝脏吸收各种营养物质，代谢葡萄糖、蛋白质、脂质和药物，并通过血流系统地输送代谢物。我们已经证明，动脉粥样硬化、糖尿病、癌症和炎症等与营养相关的疾病部分是由肝脏吸收过多营养的功能障碍引起的。我们建立了肝脏相关疾病的概念，并展示了疾病肝脏诊断和治疗发展的基本发现。

项目成果

Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes

• DOI: 10.1016/j.bbrc.2007.07.006
• 发表时间: 2007-09-21
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takamura, Toshinari;Honda, Masao;Kaneko, Shuichi
• 通讯作者: Kaneko, Shuichi

Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

• DOI: 10.1038/onc.2009.504
• 发表时间: 2010-04-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Wu, Y.;Wang, Y. Y.;Mukaida, N.
• 通讯作者: Mukaida, N.

Enhancement of tumor-specific T cell responses by transcatheter arterial embolization wit dendritic cell infusion for hepatocellular carcinoma.

通过经导管动脉栓塞和树突状细胞输注增强肝细胞癌的肿瘤特异性 T 细胞反应。

• 发表时间: 2010
• 期刊: Int J Cancer
• 影响因子: 6.4
• 作者: Miyai K;Yoneda M;Hasegawa U;Toida S;Izu Y;Hemmi H;Hayata T;Ezura Y;Mizutani S;Miyazono K;Akiyoshi K;Yamamoto T;Noda M.;Terasaki T;K. Tsutsui;E Mizukoshi
• 通讯作者: E Mizukoshi

Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immnrtalized cells

乙型肝炎病毒 X 蛋白克服了致癌 RAS 诱导的人永生化细胞衰老

• 发表时间: 2007
• 期刊: Cancer Sci 98
• 作者: Murata Y.;Yasuo T.;Yoshida R.;Obata K.;Yanagawa Y.;Margolskee RF.;Ninomiya Y.;N 0ishi
• 通讯作者: N 0ishi

遺伝子発現プロファイルによる消火器癌, 胃癌, 大腸癌及び膵臓癌の検出

通过基因表达谱检测灭火器癌、胃癌、结直肠癌和胰腺癌

• 发表时间: 2009