The development of increasing the energetic efficiency of failing heart : Application of Emax and PVA
提高心力衰竭患者能量效率的进展:Emax和PVA的应用
基本信息
- 批准号:07508003
- 负责人:
- 金额:$ 17.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1997
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We found that all postextrasystolic contractile potentiation decayd in alternans with the exception of particular cases in excised cross-circulated canine left ventricles even under physiological conditions. Our analysis showed the transient alternans to consist of two comoponens, exponential and sinusoidal decay. So we hypothesized that the normalized pressure (y) of postextrasystolic beats (beat number x) could be expressed by the following equation.y=a ・ exp [- (x-1) /tau_e] +b ・ exp [- (x-1) /tau_s] Xcos [pi (x-1)] +1This equation very closely fitted the alternans data with a squared corelation coefficient of 0.9996 on average. Then, we speculated that the exponential component of this equation would be related to the intracellular Ca ^<2+> recirculation fraction (RF) and the sinusoidal component to Ca^<2+> handling by the sarcoplasmic reticulum.We investigated the effects of intracoronary Ca^<2+> and epinephrine on the intracellular Ca^<2+> RF and total Ca^<2+> handling in the lef … More t ventricle. RF was calculated from tau_s by exp (-1/tau_s). Ca^<2+> slightly increased RF but epinephrine scarcely affected it althoug both drugs enhanced Emax (an index of con) 2-3 times. We also obtained the total amount of Ca^2 handled in one cardiac cycle by combining these RF data with Ca^<2+> handling Vo_2 data.We observed disproportionately high E-C coupling Vo_2 and decreased RF when intracoronarily infused ryanodine (approximately 40nmol/l blood for 1h) decreased Emax. We considered that the decreased RF indicated wasteful myocardial Ca^<2+> handling for a greater fraction of transsarcolemmal Ca^<2+> handling which was half economical of intracellular Ca^<2+> handling via the sarcoplasmic reticulum.We conclude that analysis of postextrasystolic potentiation in various situation s enables us to better understand pathophysiology of failing hearts and to evaluate pharmacology of cardiotonic agents from anew stand point. No other methods can evaluate intracellular total Ca^<2+> handling in the whole heart like this method. Less
我们发现,除了在切除的交叉循环犬左心室中的特殊情况外,即使在生理条件下,所有的期外收缩后收缩增强都会衰减,因此我们认为瞬态交替由两种成分组成,即指数衰减和正弦衰减。期外收缩后搏动(搏动数 x)的归一化压力(y)可用下式表示。 y=a · exp [- (x-1) /tau_e] +b · exp [- (x-1) /tau_s] Xcos [pi (x-1)] +1 该方程非常接近地拟合alternans 数据,平均平方相关系数为0.9996。然后,我们推测该方程的指数分量将与细胞内 Ca^<2+> 再循环分数 (RF) 和 Ca^<2+> 的正弦分量相关我们研究了冠状动脉内 Ca^<2+> 和肾上腺素对细胞内 Ca^<2+> RF 的影响,并计算了左心室总 Ca^<2+> 处理。从 tau_s 到 exp (-1/tau_s),Ca^<2+> 略微增加 RF,但肾上腺素几乎不影响它,尽管两种药物都增强了 Emax(a)。我们还通过将这些 RF 数据与处理 Vo_2 数据的 Ca^2+ 结合起来计算一个心动周期中处理的 Ca^2 总量。我们观察到不成比例的高 E-C 耦合 Vo_2 并降低了获得的 RF当冠状动脉内输注兰诺定(约40nmol/l血液,持续1小时)时,Emax降低,我们认为RF的降低表明心肌Ca^2+处理的浪费。跨肌膜 Ca^<2+> 处理的比例比通过肌浆网的细胞内 Ca^<2+> 处理经济一半。我们得出的结论是,对各种情况下的期外收缩后增强的分析使我们能够更好地了解衰竭心脏的病理生理学和从新的角度评价强心剂的药理学,没有其他方法可以像这种方法那样评价整个心脏的细胞内总Ca^<2+>处理。
项目成果
期刊论文数量(51)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yasuhara S, Takaki M, Kikuta A, Suga H: "Myocardial Vo_2 of mechanically unloaded contraction of rat ventricular slices measured by a new approach." American Journal of Physiology. 270. H1063-H1070 (1996)
Yasuhara S、Takaki M、Kikuta A、Suga H:“通过新方法测量大鼠心室切片机械卸载收缩的心肌 Vo_2。”
- DOI:
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- 影响因子:0
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- 通讯作者:
Mikane T, Araki J, Kohno K, Nakayama Y, Suzuki S, Shimizu J, Matsubara H, Hirakawa M, Takaki M, Suga H: "Mechanism of constant contractile efficiency under cooling inotropy of myocardium : simulation." American Journal of Physiology. 42. H2891-H2898 (1997
Mikane T、Araki J、Kohno K、Nakayama Y、Suzuki S、Shimizu J、Matsubara H、Hirakawa M、Takaki M、Suga H:“心肌冷却正性肌力作用下恒定收缩效率的机制:模拟。”
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- 影响因子:0
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Matsushita T, Takaki M, Fujii W, Matsubara H, Suga H: "Left ventricular mechanoenergetics under altered coronary perfusion in guinea pig hearts." Japanese Journal of Physiology. 45. 991-1004 (1995)
Matsushita T、Takaki M、Fujii W、Matsubara H、Suga H:“豚鼠心脏冠状动脉灌注改变下的左心室机械能学。”
- DOI:
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- 影响因子:0
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- 通讯作者:
Shimizu J,Takaki M,Kohno K,Araki J,Matsubara H,Suga H: "Sinusoidal and exponetial decays of postextrasystolic transient alternans in excised blood-perfused canine hearts." Japanese Journal of Physiology. 45. 837-848 (1995)
Shimizu J,Takaki M,Kohno K,Araki J,Matsubara H,Suga H:“在切除的血液灌注犬心脏中,期外收缩后短暂交替的正弦和指数衰减。”
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- 影响因子:0
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Ito H,Takaki M,Yamaguchi H,Tachibana H,Suga H: "Left ventricular volumetric conductance catheter for rats." American Jpurnal of Physiology. 270. H1509-H1514 (1996)
Ito H、Takaki M、Yamaguchi H、Tachibana H、Suga H:“大鼠左心室容积电导导管。”
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- 影响因子:0
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SUGA Hiroyuki其他文献
SUGA Hiroyuki的其他文献
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{{ truncateString('SUGA Hiroyuki', 18)}}的其他基金
Development of Novel Stereoselective Molecular Transformations based on Ylide Activation, and Their Synthetic Applications
基于叶立德活化的新型立体选择性分子转化的发展及其合成应用
- 批准号:
15K05497 - 财政年份:2015
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of progressive asymmetric syntheses of alkaloid based on construction of heteroatom bridged compounds
基于杂原子桥联化合物构建的生物碱渐进不对称合成方法的进展
- 批准号:
24550116 - 财政年份:2012
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$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of wide scope asymmetric dipolar cycloaddition reactions and its synthetic applications
广泛的不对称偶极环加成反应的发展及其合成应用
- 批准号:
20200052 - 财政年份:2008
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
Development of wide scope asymmetric synthesis of oxygen-bridged polycyclic compounds and its synthetic applications
氧桥多环化合物的宽范围不对称合成及其合成应用的进展
- 批准号:
20550094 - 财政年份:2008
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Asymmetric Reactions of Diazo Carbonyl Compounds in the Presence of Metal-Catalysts having Axial Chirality
具有轴向手性的金属催化剂存在下重氮羰基化合物的不对称反应的进展
- 批准号:
11640530 - 财政年份:1999
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approach
通过分析期外收缩后增强和 OD22 D2 消耗来评估 E-C 耦合中处理的 CA D12+D1 总量:系统方法
- 批准号:
10558136 - 财政年份:1998
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Macro-micro correspondence in mechanoenagetics of failing hearts
衰竭心脏机械动力学中的宏观与微观对应
- 批准号:
09470009 - 财政年份:1997
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The development of evaluating method for oxygen wasting effects by cardiotonic agents
强心剂耗氧效应评价方法的建立
- 批准号:
04557041 - 财政年份:1992
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Methods to improve cardiac efficiency and load matching.
提高心脏效率和负荷匹配的方法。
- 批准号:
63570045 - 财政年份:1988
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approach
通过分析期外收缩后增强和 OD22 D2 消耗来评估 E-C 耦合中处理的 CA D12+D1 总量:系统方法
- 批准号:
10558136 - 财政年份:1998
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Macro-micro correspondence in mechanoenagetics of failing hearts
衰竭心脏机械动力学中的宏观与微观对应
- 批准号:
09470009 - 财政年份:1997
- 资助金额:
$ 17.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)