STUDY ON THE DEVELOPMENT OF THE SCORE AS AN INDEX FOR THE EEFECT OF POLYPHENOL-CONTAINING FOODS ON THE REDUCTION OF BLOOD GLUCOSE LEVEL

含多酚食品降低血糖效果指数的研究

基本信息

批准号：
18500627
负责人：
TSUJI Hideaki
金额：
$ 2.57万
依托单位：
Okayama Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Life-style-induced disease is a critical social problem. Diabete is one of the life-style-induced diseases. The disease consists of two types, namely I-type which is dependent on insulin, and IItype, which is nondependent on insulin. The latter type accounts for more than 95% of total diabetic patients. In order to cure and prevent the omset of the insuline-nondependent, a drug such as Acalbose and functional foods including functional components such as wheat albumin, quava polyphenol and digestion-resitant polydextrose have been utilized At present, other functional components than the above-mentioned components are expected to be developed.In order to establish an index assessing the effect of polyphenol-containing foods on reduction of blood glucose level, it is very important to elucidate the functional components in the foods responsible for the reduction of blood glucose level We carried out the investigation on polyphenol compounds in foods actively. Consequently, we found out chlorogenic acid as a functional components inducing the reduction of blood glucose level Furthermore, catechins and quercetin were shown to show the functionality inducing the reduction of blood glucose level o among the known polyphenol compounds. Interestingly, these polyphenol components were shown to exhibit the regulation of the blood glucose level by inhibition α-glucosidase activity such as sucrase and maltase.We found out the occurrence of chlorogenic acid derivatives in the leavers of white sweet potato called Kibimidori in Okayama region. These chlorogenic acid derivatives were shown to show more powerful inhibitory activity for α-glucosidase activity than chlorogenic acid, quecetin and catechins. This finding indicates that these components are candidate as afunctional components responsible for the reduction of blood glucose level.

生活方式诱发的疾病是严重的社会问题。糖尿病是生活方式诱发的疾病之一，该疾病分为两种类型，即依赖胰岛素的I型和不依赖胰岛素的II型。后者占糖尿病患者总数的95%以上。为了治疗和预防非胰岛素依赖型糖尿病，需要使用阿卡波糖等药物和包括小麦白蛋白、番石榴多酚等功能性成分的功能性食品。目前，除了上述成分外，其他功能成分有望被开发出来。建立一个评价含多酚食品降低血糖效果的指标非常重要为了阐明食品中负责降低血糖水平的功能成分，我们对受试食品中的多酚化合物进行了研究，发现绿原酸是一种降低血糖水平的功能成分。在已知的多酚化合物中，儿茶素和槲皮素显示出诱导血糖水平的功能。我们在冈山地区的白甘薯叶中发现了绿原酸衍生物。这些绿原酸衍生物。被证明表现出更强大的抑制活性α-葡萄糖苷酶活性高于绿原酸、槲皮素和儿茶素，这一发现表明这些成分是负责降低血糖水平的候选功能成分。