Basic study in effectiveness and safety of liquid ventilation for severe respiratory failure

液体通气治疗严重呼吸衰竭有效性和安全性的基础研究

基本信息

批准号：
17591884
负责人：
MATSUDA Kenichi
金额：
$ 2.44万
依托单位：
University of Yamanashi
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591884/
关键词：
respiratory failure lung injury liquid ventilation artificial ventilatory support fluorocarbon Emergency medicine intensive care medicine critical care medicine

项目摘要

The concept of liquid ventilation (LV) has been investigated over the past three decades. Numerous studies have evaluated the ability of perfluorocarbon fluids to enhance gas exchange and pulmonary function in the setting of lung injury. The mechanism of gas exchange is quite different during between gas ventilation and liquid ventilation. However there are very few studies to investigate the setting of ventilation to maximum gas exchange and pulmonary function during liquid ventilation. In this study, we performed a basic study for electiveness and safety of liquid ventilation in a rat model First, P_aCO2 and P_aO2 were analyzed during between gas ventilation and partial liquid ventilation in the various operational conditions (minute volume: 167, 200, 267 mL/min, respiratory rate: 40, 50, 60, 70, 80, 90 /min, I : E : 1 : 2, 1 : 1). Second, the effect of ventilation settings to gas exchange and pulmonary function were compared during between gas ventilation and partial liquid ventilation in a rat model. It was revealed that the effect of ventilation settings to gas exchange and pulmonary function during liquid ventilation is larger than during gas ventilation. We conclude that gas exchange and pulmonary function such as P_aCO2 and P_aO2 should be monitored carefully during liquid ventilation in the treatment of the patients with severe respiratory failure.

在过去的三十年中，已经研究了液体通风（LV）的概念。大量研究评估了全氟化合物在肺损伤中增强气体交换和肺功能的能力。在气通气和液体通风之间，气体交换的机制大不相同。但是，很少有研究研究在液体通风期间的通风设置为最大气体交换和肺功能。在这项研究中，我们对大鼠模型中的液体通风的选择性和安全性进行了一项基础研究，在各种操作条件下，在气通气和部分液体通风之间进行了P_ACO2和P_AO2（分钟：167，200，267 ML） /min，呼吸速率：40、50、60、70、80、90 /min，i：e：1：2、1：1）。其次，在大鼠模型中，在气通气和部分液体通风之间比较了通风设置对气体交换和肺功能的影响。据表明，通风设置对液体通风期间气体交换和肺功能的影响大于气通气期间。我们得出的结论是，在液体通风期间应仔细监测气体交换和肺功能，例如P_ACO2和P_AO2，以治疗严重的呼吸衰竭患者。