New optical brain imaging in infants by using near-infrared diffuse optical tomography

使用近红外漫射光学断层扫描对婴儿进行新的光学脑成像

• 批准号: 17390307
• 负责人: KUSAKA Takashi
• 金额: $ 5.82万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390307/
• 关键词: Near-infrared spectroscopy; Optical tomography; Infant; Hypocapnea; Cerebral blood volume; Periventricular leukomalasia; Time-resolved spectroscopy; Cerebral Hb oxygen saturation; 低出生体重児; 脳内血液量; 脳内ヘモグロビン酸素飽和度; 吸収係数; 散乱係数; トモグラフィー; 新生児; 脳

An optical 3D imaging method using near-infrared diffuse optical tomography (NIR DOT) to estimate the regional light scattering and absorption properties in infants has been developed. The NIR DOT system is consisted of 16 source-detector fibers, pulsed diode lasers operating at the wavelengths of 759 and 835 nm and time correlated single photon counting units. The image reconstruction algorithm is based on the modified generalized pulsed spectral technique. The time-resolved data were used to estimate for concentration of oxyHb and deoxyHb.DOT was measured in an infant on 29 days after birth, whose gestational age and birth weight was 23 weeks and 658g, assisted by an artificial respirator. Informed consent in writing was obtained from the parents, and the study was approved by the local ethics committee.The data under two different state, (A) normocapnea and (B) hypocapnea induced by hyperventilation, were obtained. DOT images showed the Hb concentrations obtained at the state (B) subtracted by (A). The results showed that the total Hb concentration in the most parts of the brain decreased, reflecting the decrease in cerebral blood flow, especially white matter regions. The results demonstrated that NIR DOT is capable of reconstructing the images of Hb concentration with a high spatial resolution in infants at the bedside.

已经开发了一种使用近红外弥散光学层析成像（NIR DOT）来估计婴儿中的区域光散射和吸收特性的光学3D成像方法。 NIR点系统由16个源探测器纤维组成，脉冲二极管激光器以759和835 nm的波长工作以及时间相关的单个光子计数单元。图像重建算法基于修改的广义脉冲光谱技术。时间分辨的数据用于估计氧气浓度和脱氧b的浓度。在出生后29天，在婴儿中测量了一个婴儿，其妊娠年龄和出生体重为23周且658G，并在人工呼吸器的辅助下进行。以书面形式获得了知情同意书，并获得了当地伦理委员会的批准，该研究获得了两个不同状态下的数据，（a）正常流动性和（b）通过过度换气诱导的次生型。点图像显示在（a）减去状态下获得的HB浓度。结果表明，大脑大部分地区的总HB浓度降低，反映了脑血流的降低，尤其是白质区域。结果表明，NIR DOT能够重建床边婴儿的HB浓度图像，并具有很高的空间分辨率。

项目成果

Study for diffuse optical tomography in premature infant. Dept of Mech. Rug. end Intel.

早产儿弥散光学断层扫描研究。

• 发表时间: 2007
• 期刊: Sys., University of Electro-Commusicatione, Japan. A graduation thesis (in Japanese)
• 作者: Masanori Ueno;Ryo Fukuzawa;Shinpei Okawa;Yukio Yasnada;Takashi Kusaka;Tomoko Nishida;Kenichi bobs;Yukari Tanikawa;Feng Gao;Cbie Sato;Yoko Hoshi.;Masanori Ueno.;Ryo Fukuzawa.
• 通讯作者: Ryo Fukuzawa.

Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction

持续等长收缩过程中肌肉氧合与肌电活动的关系

• 发表时间: 2008
• 期刊: Clin Physiol Funct Imaging 28 (4)
• 作者: Yamada E;Kusaka T;Arima N;Isobe K;Yamamoto T;Itoh S.
• 通讯作者: Itoh S.

Functional optical hemodynamic imaging of the olfactory cortex

• DOI: 10.1097/mlg.0b013e31802ffe2a
• 发表时间: 2007-03-01
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Kobayashi, Eiji;Kusaka, Takashi;Mori, Nozomu
• 通讯作者: Mori, Nozomu

In vitro production of bilirubin photaisomers by light ircadiation using neoBLUE.

使用 neoBLUE 通过光照射体外生产胆红素光异构体。

• 发表时间: 2007
• 期刊: irediatr tnt. 49(3)
• 作者: Okada H;Abe T;Etoh Y;Yosbino S;Kate I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;Nemba M;Nisbitla T;Imai T;Isobe K;Itoh S.
• 通讯作者: Itoh S.

In vitro production of bilirubin photoisomers by light irradiation using neoBLUE

使用 neoBLUE 通过光照射体外生产胆红素光异构体

• 发表时间: 2007
• 期刊: Pediatr Int. Jun;49(3)
• 作者: Okada H;Abe T;Etoh Y;Yoshino S;Kato I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;et. al.
• 通讯作者: et. al.