Metal contamination and chromosome instability in a population around Chernobyl Nuclear Power Plant

切尔诺贝利核电站周围人群的金属污染和染色体不稳定

• 批准号: 16406020
• 负责人: SAITO Hiroshi
• 金额: $ 7.1万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16406020/
• 关键词: Chernobyl; Heavy metal contamination; Iodine; Thyroid Cancer; Porphyrin; 染色体不安定性; CGH

Although it is well know that childhood thyroid cancer has been dramatically increased after the accident at the Chernobyl Nuclear Power Plant on 1983, little is known on its mechanism. On the other hand, it has been recently reported that heavy metals, such as leads was released to the contaminated areas for the purpose of the decontamination, and the contamination map of these metals has been prepared. However, there is no report on the health effects in population residing in this area. Recently, it has been reported the chromosomal instability by the exposure of heavy metals such as cadmium and nickel in vitro, which suggests that metal exposure might be a cause of chromosomal instability, same as radiation exposure. In this point of view, we aimed to evaluate the current situation of heavy metal contamination in this area, and clarify the chromosomal changes, in cooperation with the Institute of Radiation Medicine of Ukraine (Kiev).Based on the previous results, we evaluated the contamination levels of heavy metals using hairs, but no significant correlation was observed with soil contamination levels. On the other hand, a certain trace element was elevated, which suggests that further evaluation is needed.On July 2006, we conducted the international symposium at Nagasaki University, to review our research activity during three years. Simultaneously, we invited specialist from China and the Republic of Belarus, in order to expand our research network in this area.

尽管众所周知，1983年切尔诺贝利核电站事故发生后，儿童甲状腺癌已大大增加，但其机制知之甚少。另一方面，最近有报道说，为了进行净化而将重金属（例如铅）释放到受污染的区域，并准备了这些金属的污染图。但是，没有关于该领域居住的人口的健康影响的报告。最近，据报道，通过在体外暴露于镉和镍等重金属，这表明金属暴露可能是导致染色体不稳定性的原因，这与辐射暴露相同。从这个角度来看，我们旨在评估该领域重金属污染的当前状况，并阐明与乌克兰辐射医学研究所（基辅）合作的染色体变化（基于先前的结果），我们评估了该结果。使用头发的重金属的污染水平，但没有观察到土壤污染水平的显着相关性。另一方面，某个痕量要素被提升，这表明需要进一步评估。2006年7月，我们在长崎大学进行了国际研讨会，以审查三年内的研究活动。同时，我们邀请了来自中国和白俄罗斯共和国的专家，以扩大我们在该领域的研究网络。

项目成果

Adenovirus-mediated gene delivery of interleukin-10, but not transforming growth factor β, ameliorates the induction of Graves' hyperthyroidism in BALB/c mice.

腺病毒介导的白细胞介素 10 基因递送（但不包括转化生长因子 β）可改善 BALB/c 小鼠中格雷夫斯甲状腺功能亢进症的诱导。

• 发表时间: 2005
• 期刊: Clin Exp Immunol 141・3
• 作者: Akizhanova A;Takamura N他;Morita N他;Nakazawa T他;Saitoh O他
• 通讯作者: Saitoh O他

Folic acid deficiency : main etiological factor of megaloblastic anemia in Kazakhstan?

叶酸缺乏：哈萨克斯坦巨幼细胞贫血的主要病因？

• 发表时间: 2006
• 期刊: Am J Hematol 81・6
• 作者: Akilzhanova A;Takamura N他
• 通讯作者: Takamura N他

Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults.

日本健康年轻人心血管危险因素和相关临床标志物的评估。

• 发表时间: 2007
• 期刊: Intemational Dental Joumal 57
• 作者: 江本智子;上田真寿美;松田昌子;杉野法広;Yagura C
• 通讯作者: Yagura C

Thyroid blockade during a radiation emergency in iodine-rich areas : effect of a stable-iodine dosage.

碘丰富地区辐射紧急情况下的甲状腺封锁：稳定碘剂量的影响。

• 发表时间: 2004
• 期刊: J Radiat Res 45・2
• 作者: Fabian MM;Takamura N 他
• 通讯作者: Takamura N 他

RET Oncogene Amplijfication in Thyroid Cancer : Correlations with Radiation associated and High-grade Malignancy.

甲状腺癌中的 RET 癌基因扩增：与辐射相关和高级别恶性肿瘤的相关性。

• 期刊: Human Pathol (印刷中)
• 作者: Nakashima M;Takamura N他
• 通讯作者: Takamura N他