Restoration of the visual function by electrical stimulation to the neural column

通过电刺激神经柱恢复视觉功能

• 批准号: 15300202
• 负责人: YOSHIMINE Toshiki
• 金额: $ 8.7万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300202/
• 关键词: visual restoration; electrical stimulation; visual prosthesis; transcranial magnetic stimulation; magnetoencephalography; 人工視覚; 視覚障害; 開口合成法

1.Behavioral changes during electrical stimulation on the rat visual cortexA blind rat model was made by resecting bilateral optic nerves. A needle electrode was inserted in the IV layer of the visual cortex. Exploring behavior was decreased by electrical stimulation to the visual cortex but not to the sensorimotor cortex. These results suggested that the electrical stimulation to the visual cortex acts as sensory stimulation2.Electrical stimulation and recording from a micro-multielectrode using ratsPhotic retinal stimulation and electrical cortical stimulation were compared during recording the rat's visual cortex using a micro-multielectrode. Single pulse electrical stimulation to the primary visual cortex evoked the spikes around the visual cortex Joint PSTH analyses revealed that the functional connectivity between the evoked spikes had partial similarity in spatial distribution between photic stimulation and electrical stimulation3.Visual sensation induced by occipital transcrani … More al magnetic stimulation (TMS)TMS to the occipital cortex was performed for healthy subjects and patients with severe visual disturbance. Induced visual sensation was measured quantitatively. Single or repetitive stimuli were delivered. In healthy subjects, visual sensations were consistently induced by repetitive TMS, and their locations and characteristics were well concordant with basic neuro-anatomical findings. Further investigation would be needed to apply this method to the indication of cortical visual prosthesis4.Synthetic aperture magnetometry (SAM) of the visual cortexTo establish the evaluation of the cerebral visual function, local oscillatory changes induced by wide-visual-angle pattern reversal stimulation using SAM for healthy subjects and patients with visual disturbance. Optimal stimulation in quadrant field stimulation was also investigated. Gamma synchronization and alpha/beta desynchronization were consistently demonstrated in the visual cortex in healthy subjects, whereas the location and frequency of the peak oscillatory changes were sensitively shifted due to the lesion. Further improvement would be needed to establish quadrant field stimulation Less

1.电刺激大鼠视觉皮层时的行为变化通过切除双侧视神经制作盲鼠模型，在视觉皮层的IV层插入针电极，电刺激视觉皮层时探索行为减少，但不减少。这些结果表明，对视觉皮层的电刺激起到了感觉刺激的作用。2.使用大鼠的微型多电极进行电刺激和记录，在记录过程中比较了光视网膜刺激和电皮层刺激。使用微型多电极对大鼠的视觉皮层进行单脉冲电刺激，诱发视觉皮层周围的尖峰。联合 PSTH 分析表明，所诱发的尖峰之间的功能连接在光刺激和电刺激之间的空间分布上具有部分相似性。枕叶经颅磁刺激（TMS）对健康受试者和患有严重视觉障碍的患者进行枕叶磁刺激（TMS）进行定量测量。在健康受试者中，视觉感觉是由重复的 TMS 持续诱导的，其位置和特征与基本的神经解剖学发现非常一致，需要进一步研究将该方法应用于皮质视觉假体的适应症。视觉皮层合成孔径磁力测量（SAM）建立对健康受试者和视力障碍患者的大脑视觉功能、广角模式反转刺激引起的局部振荡变化的评估还研究了健康受试者视觉皮层中的伽玛同步和α/β去同步的最佳刺激，而峰值振荡变化的位置和频率由于病变而发生了敏感的变化。需要建立象限场刺激 更少

项目成果

機能的大脳半球切除術

功能性大脑半球切除术

• 发表时间: 2006
• 期刊: 脳神経外科ジャーナル 15・3
• 作者: 加藤;天美
• 通讯作者: 天美

難治性疼痛に対する脳皮質刺激療法

脑皮质刺激疗法治疗顽固性疼痛

• 发表时间: 2003
• 期刊: 脳神経外科速報 13
• 作者: Youichi Saitoh;富永 篤;有田 和徳;Kato Amami;Eguchi Yutaka;Arita K;Saitoh Y;富永 篤;Saitoh Y;Tomishima T;有田 和徳;Yenomas DC;Soichi Obara;Kanou Y;二宮宏智;Arita K;Hideo Takeshima;Tomoaki Goto;齋藤洋一
• 通讯作者: 齋藤洋一

視覚課題への注意が体性感覚処理に及ぼす影響

视觉任务注意力对体感处理的影响

• 发表时间: 2005
• 期刊: 臨床脳波 47・7
• 作者: Miyanari A;Hirayama A;加藤天美;Miyanari A;Hirayama A;Kinoshita M;Fujimoto Y;Kato A;Taniguchi M;高橋優
• 通讯作者: 高橋優

インターフェイス装置、インターフェイス方法及びその装置を用いた制御訓練装置

接口装置、接口方法以及使用该装置的控制训练装置

• 发表时间: 2004

脳神経外科学体系 10巻 定位・機能神経外科 第1章 総論,疫学と病態生理

神经外科系统第 10 卷立体定向/功能神经外科第 1 章概述、流行病学和病理生理学

• 发表时间: 2005
• 作者: 中谷靖彦;吉中孝志;海野勇三;友定保博;齋藤洋一;齋藤洋一;Ihara A;Ihara A;Saitoh Y;Hirata M;松田恵示;Kato A et al.;Kato A et al.;松田恵示;加藤天美
• 通讯作者: 加藤天美