Non invasive 3-demensional measurement of brain function with developed synthetic aperture magnetometry

利用先进的合成孔径磁力测量技术对脑功能进行无创三维测量

基本信息

批准号：
11470290
负责人：
YOSHIMINE Toshiki
金额：
$ 8.51万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The equivalent current dipole (ECD) method conventionally used for analysis for magnetoencephalography represent the activated brain area as one or small number of dipoles. It is not enough for comprehensive understanding of the brain activity, since the functional process of the brain is derived from the activation of neurons in a certain volume of cortex and ECD only displays the center of gravity of activated brain as a representative single point. We applied recently developed synthetic aperture magnetometry (SAM) with a spatially-selective beamformer, which filters out the background brain noise from other regions to obtain the meaningful signals from the arbitrary target regions. The neuromagnetic signals are transformed into units of dipole moment on a per voxel basis ; this enables one to measure the current density of the small portion of the brain with an enhanced sensitivity (SAM virtual sensor method). With further application of statistical imaging technique, statistical d … More ifference in the power of selected frequency band can be evaluated between the active and control states. Those areas with statistical difference can be displayed on the individual MRI in a tomographic manner (SAM statistical method). In this study, following neuro-functional processes were analyzed. Owing to the superior spatial resolution of the MEG and to the novel filtering technique of SAM, the tomography of neuromagnetic event related synchronization (ERS) or desynchronization (ERD) evoked by neurological task was demonstrated for the whole brain.1. Motor-related brain activityThe influence of the hemispheric dominance as well as hand dominance wasdisclosed.2. Sensory-related brain activitySimultaneous and multifocal brain activations with very high frequency oscillation were disclosed.3. Language-related brain activityBoth sensory and motor language area were demonstrated with reading without phonation task.4. EpilepsyThe SAM virtual sensor method demonstrated the origin and the propagation process of epileptic discharges as if the intracranial electrodes were implanted. The elimination of invasive monitoring was implied. Less

常规用于分析磁脑摄影的等效电流偶极子（ECD）方法表示活化的大脑面积是一个或少量的偶极子。这还不足以全面了解大脑活动，因为大脑的功能过程源自一定体积的皮质和ECD中神经元的激活，而ECD仅显示活化大脑的重心作为代表性的单点。我们应用了最近使用空间选择光束器的合成光圈磁力测定法（SAM），该光束仪将来自其他区域的背景脑噪声滤除，以从任意目标区域获得有意义的信号。每次体素的基础上，神经磁信号转化为偶极矩的单位。这使人们能够以增强的灵敏度（SAM虚拟传感器方法）来测量大脑小部分的当前密度。通过进一步应用统计成像技术，可以在主动状态和对照状态之间评估所选频带的功率的统计d…更多的违规行为。那些具有统计差异的区域可以以层析成像方式显示在单个MRI上（SAM统计方法）。在这项研究中，分析了神经功能过程之后。由于MEG的上空间分辨率和SAM的新型过滤技术，神经磁性事件相关同步（ERS）的层析成像或由神经系统任务引起的Dennchronic（ERD）（ERD）被证明了整个大脑的整个大脑。1。与运动相关的大脑活性，半球优势和手部占主导地位的影响。2。透露了与感觉相关的大脑活动和多灶性脑激活，并且透露频率很高。3。通过阅读而无需发音任务，证明了与语言相关的大脑活动的感觉和运动语言区域。4。癫痫病SAM虚拟传感器方法证明了癫痫放电的起源和传播过程，就好像植入了颅内电极一样。消除了侵入性监测。较少的