Development of a Blood Glucose Control System for Postoperative Diabetics

糖尿病术后血糖控制系统的开发

基本信息

批准号：
14550444
负责人：
ARAKI Mituhiko
金额：
$ 1.98万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Today, surgical operations on elderlies and diabetics are often performed. After surgical operations, they would sometimes come down with hyperglycemia, which is called "postoperative diabetes." Since this might result in infection, anastomic failure, or other complications, insulin is infused by medical staffs. The infusion rate of insulin has to be accurately adjusted, because patients would fall into hypoglycemia if an excessive amount of insulin is infused, and because blood glucose level would not become low enough if a sufficient amount of insulin is not infused. However, it is not easy to manipulate the insulin infusion rate to maintain the blood glucose within the desired range because the response of blood glucose to insulin is widely varying during a few days after surgery.In this research, we have studied 1)the model of the blood glucose regulatory system of postoperative diabetics, and 2)a blood glucose control method for postoperative diabetics. The obtained results are as follows.●From the results of animal experiments, Karlsburg model is the most appropriate model of blood glucose regulatory system in the time-invariant case among the representative models proposed in the past.●The blood glucose response of postoperative diabetics can be modeled as a second order state equation with a dead-time.●The change of the blood glucose response with time to insulin can be represented as the change of the gain of the blood glucose regulatory system.●The state-predictive controller with an auto-tuning function developed for blood glucose control of diabetics without a knowledge of individual parameters is effective as the controller for postoperative diabetics.

如今，经常进行有关老年人和糖尿病患者的外科手术。手术手术后，有时会因高血糖症而降低，这被称为“术后糖尿病”。由于这可能导致感染，吻合术衰竭或其他并发症，因此胰岛素被医务人员注入。必须对胰岛素的输注率进行准确调节，因为如果胰岛素含量过多，患者将陷入低血糖，并且由于未注入足够量的胰岛素，血糖水平不会变得足够低。然而，操纵胰岛素输注率并不容易维持在所需范围内的血糖，因为在手术后的几天内，血糖对胰岛素的反应在很大程度上变化。获得的结果如下。●从动物实验的结果中，卡尔斯堡模型是在过去不变的情况下，在过去的代表性模型中，最合适的血糖调节系统模型。●术后糖尿病患者的血糖反应可以与静止的时间相对于死亡的时间来模仿eSsection play wister wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste wiste。血糖调节系统的增益。●具有自动调节功能的国家预测控制器，不知道糖尿病患者的血糖控制，而无需了解各个参数，作为术后糖尿病患者的控制者。