Pathophysiological study on the effects of shift work on cardiovascular diseases

轮班工作对心血管疾病影响的病理生理研究

• 批准号: 13670387
• 负责人: MURATA Katsuyuki
• 金额: $ 2.62万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670387/
• 关键词: Shift work; Autonomic function; Cardiovascular disease; Pathophysiology; Parasympathetic activity; Sympathetic activity; 交換神経活動; 心電図QTc間隔; 心電図RR間隔変動; リスクファクター

The purpose of this study was to clarify the pathophysiological effects of shift work on cardiovascular diseases. The study population consisted of 156 male shift workers and 90 male day workers who had been employed at a copper-smelter plant. The heart rate-adjusted QT interval (QTc) on ECG, total power spectral density (t-PSD) of 100 RR intervals, PSDs with frequencies of 0.04-0.15 Hz and of 0.15-0.4 Hz (PSD_<LF> and PSD_<HF>), RR interval variability (CV_<RR>), LF- and HF-component variability (C-CV_<LF> and C-CV_<HF>) and %LF(PSD_<LF>/(PSD_<LF>+PSD_<HF>) 100) were measured (LF and HF components are thought to reflect the sympathetic and parasympathetic activities, respectively). There were no significant differences in age, smoking habit, biochemical data or blood pressure between the shift and day workers. The QTc in the shift workers was significantly prolonged as compared to the day workers. By contrast, the C-CV_<LF> and log-transformed PSD_<LF> were significantly depressed in the shift workers. In the day workers, the QTc was significantly correlated with the log-transformed t-PSD and PSD_<HF>, C-CV_<HF> and %LF. These findings suggest that QTc prolongation in healthy men reflects depression of the cardiac autonomic function, especially parasympathetic hypoactivity. The prolonged QTc in shift workers appears to be associated with the cardiac autonomic hypofunction, partly due to sympathetic hypoactivity. For the prevention of cardiovascular mortality in shift workers, minimizing further occupational stress that can reduce the parasympathetic activity, except shift work, may be important.

这项研究的目的是阐明转移工作对心血管疾病的病理生理影响。该研究人群由156名男性转移工人和90名在铜工厂工作的男性日工人组成。心率调整后的QT间隔（QTC）在ECG上，总功率频谱密度（T-PSD）为100 RR间隔，PSD，频率为0.04-0.15 Hz，为0.15-0.4 Hz，PSD_ <lf>和PSD_ <lf> and PSD_ <hf>），RR Interval变异性（RR Interval interibal），cv_ <rf-cv_ <rf- <rfr> （C-CV_ <lf>和C-CV_ <hf>）和％LF（PSD_ <lf>/（PSD_ <lf>+PSD_ <hf>）100）（LF和HF组件分别反映了交感神经和副交响活动）。班次和日常工人之间的年龄，吸烟习惯，生化数据或血压没有显着差异。与日常工人相比，轮班工人中的QTC显着延长了。相比之下，在移位工人中，C-CV_ <lf>和对数转换的PSD_ <lf>显着降低。在日常工人中，QTC与对数转换的T-PSD和PSD_ <hf>，C-CV_ <HF>和％LF显着相关。这些发现表明，健康男性的QTC延长反映了心脏自主神经功能的抑郁症，尤其是副交感神经性低。移位工人中延长的QTC似乎与心脏自主神经功能障碍有关，部分原因是同情性不良。为了预防转移工人的心血管死亡率，最大程度地减少了可以减少副交感神经活动的进一步的职业压力，除了转移工作，可能很重要。

项目成果

Yokoyama K, Araki S, Yamashita K, Murata K, Nomiyama K, Nomiyama H, Tao YX, Liu SJ: "Subclinical cerebellar anterior lobe, vestibulocerebellar and spinocerebellar afferent effects in young female lead workers in China: computerized posturography with sway

Yokoyama K、Araki S、Yamashita K、Murata K、Nomiyama K、Nomiyama H、Tao YX、Liu SJ：“中国年轻女性领导工人的亚临床小脑前叶、前庭小脑和脊髓小脑传入效应：摇摆的计算机姿势描记法

Murata K, Budtz-Jorgensen E, Grandjean P: "Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children"Risk Anal. 22. 465-474 (2002)

Murata K、Budtz-Jorgensen E、Grandjean P：“两组儿童中与甲基汞相关的诱发潜在潜伏期延迟的基准剂量计算”风险分析。

Yokoyama K, Araki S, Yamashita K, Murata K, et al.: "Subclinical cerebellar anterior lobe, vestibulo-cerebellar and spinocerebellar afferent effects in young female lead workers in China: Computerized posturography with sway frequency analysis and brainst

Yokoyama K、Araki S、Yamashita K、Murata K 等人：“中国年轻女性领导工人的亚临床小脑前叶、前庭小脑和脊髓小脑传入效应：采用摇摆频率分析和脑力分析的计算机姿势描记法

Weihe P, Hansen JC, Murata K, et al.: "Neurobehavioral Performance of Inuit Children with Increased Prenatal Exposure to Methylmercury"International Journal of Circumpolar Health. 61. 41-49 (2002)

Weihe P、Hansen JC、Murata K 等人：“产前甲基汞暴露增加的因纽特儿童的神经行为表现”国际环极健康杂志。

Shinozaki T, Yano E, Murata K: "Intervention for prevention of low back pain in Japanese forklift workers"Am J Ind Med. 40. 141-144 (2001)

Shinozaki T、Yano E、Murata K：“预防日本叉车工人腰痛的干预措施”Am J Ind Med。