Subclinical effects of environmental hazardous factors on nervous and renal functions in humans

环境有害因素对人体神经和肾功能的亚临床影响

• 批准号: 17590507
• 负责人: MURATA Katsuyuki
• 金额: $ 2.3万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590507/
• 关键词: Environmental hazardous factors; Neuroscience; Preventive medicine; Critical concentration; Risk assessment; 鉛; カドミウム; 水銀; 身体重心動揺; 非顕性影響

The objectives of this research were to clarify the subclinical effects of environmental hazardous factors such as lead, cadmium, and methylmercury (MeHg), on nervous and renal functions in humans. (1) The first study was carried out to estimate the critical dose of lead affecting the neuromotor function in workers by introducing the benchmark dose (BMD) approach. Postural sway parameters with spectral analysis were compared between 121 lead workers with BPb levels of 6-89 μg/dl and 60 unexposed controls. All sway parameters, except for sagittal sways with eyes open, were significantly larger in the lead workers than in the controls. The critical dose of BPb was estimated to be 12.1-17.3 μg/dl for postural sway. (2) To investigate the relations among total mercury (THg) levels in hair, toenail, and urine, together with potential effects of MeHg intake on renal tubular function, their levels, and urinary N-acetyl-glucosaminidase activity (NAG) and α1-microglobulin (AMG) were determined … More in 59 women, and estimated daily mercury intakes from fish and other seafood using a food frequency questionnaire. THg levels in the women were 1.51±0.91 (SD) μg/g in hair, 0.59±0.32 μg/g in toenail, and 0.86±0.66 μg/g creatinine (Cre) in urine ; and, there were positive correlations among them. The daily mercury intake of 9.15±7.84 μg/day was significantly correlated with THg levels in hair, toenail, and urine. Among the women, the NAG and AMG were positively correlated with both the daily mercury intake and THg levels in hair, toenail, and urine ; and, these relations were almost similar when using multiple regression analysis to adjust for possible confounders such as urinary cadmium (0.47±0.28 μg/g Cre). In conclusion, MeHg resulting from fish consumption can explain total mercury levels in hair, toenail, and urine to some degree, partly through the degradation into the inorganic form. (3) To clarify the neuromotor effects of occupational exposure to mercury vapor, hand tremor and postural sway were measured in 27 miners and smelters and 52 unexposed subjects. The means of the urinary mercury level (UHg) were 228 μg/g Cre for the exposed workers and 2.6 μg/g Cre for the unexposed subjects. Total tremor intensity and frequency-specific tremor intensities at 1-6 and 10-14 Hz were significantly larger in the exposed workers than in the unexposed subjects, but they were not significantly related to the UHg among the exposed workers. In contrast, there were no significant differences in any postural sway parameters between the above two group, but the transversal sway with eyes open was positively related to the UHg among the exposed workers in using multiple regression analysis. These findings suggest that postural sway and hand tremor, may be affected by elemental mercury vapor exposure. Less

这项研究的目的是阐明铅，镉和甲基汞（MEHG）等环境危险因素对人类神经和肾功能的亚临床影响。 （1）第一项研究是通过引入基准剂量（BMD）方法来估计影响工人神经运动功能的临界剂量的。在121名BPB水平为6-89μg/dL和60个意外对照的主要工人之间，比较了具有光谱分析的姿势摇摆参数。除矢状参数外，所有的摇摆参数在睁大眼睛的矢状摇摆外，在主要工人中的摇摆参数明显大于对照组。对于姿势摇摆，BPB的临界剂量估计为12.1-17.3μg/dl。 （2）研究头发，趾甲和尿液中总汞（THG）水平之间的关系，以及MEHG摄入对肾小管功能的潜在影响，其水平和尿液N-乙酰基 - 葡萄糖酰胺酶活性（NAG）和α1-Microglobobobobolin（AMG）在59位女性中的次数更高，并在59位女性中进行了更多的量子和估计的次数。女性的THG水平为头发的1.51±0.91（SD）μg/g，脚趾甲中的THG水平为0.59±0.32μg/g，尿液中的THG水平为0.86±0.66μg/g肌酐（CRE）；而且，它们之间存在正相关。每日9.15±7.84μg/天的汞摄入量与头发，脚趾甲和尿液的Thg水平显着相关。在妇女中，NAG和AMG与每日汞摄入量和头发，脚趾甲和尿液的THG水平呈正相关。并且，当使用多元回归分析调整可能的混杂因子（例如0.47±0.28 µg/g CRE）时，这些关系几乎是相似的。总之，由于鱼类消耗而产生的MEHG可以在某种程度上解释头发，脚趾甲和尿液中的总汞水平，部分是通过降解为无机形式的。 （3）在27名矿工和冶炼厂以及52名意外的受试者中测量了占据汞蒸气的神经运动作用，手动震颤和姿势摇摆。对于暴露的工人，尿液汞水平（UHG）的平均值为228μg/g CRE，意外受试者的平均值为2.6μg/g CRE。在裸露的工人中，在1-6和10-14 Hz处的总震颤强度和频率特异性的震颤强度明显大于意外受试者，但与裸露的工人之间的UHG没有显着相关。相比之下，上述两组之间的任何姿势摇摆参数没有显着差异，但是在使用多重回归分析时，露出眼睛的横向摇摆与裸露的工人之间的UHG呈正相关。这些发现表明，姿势摇摆和手震颤可能会受到元素汞蒸气的影响。较少的

项目成果

Cardiac autonomic hypofunction in preschool children with short nocturnal sleep

• DOI: 10.1620/tjem.208.235
• 发表时间: 2006-03-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Sampei, M;Murata, K;Wood, DC
• 通讯作者: Wood, DC

Impact of total sleep duration on blood pressure in preschool children

• DOI: 10.2220/biomedres.27.111
• 发表时间: 2006-06-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Sampei, Mari;Dakeishi, Miwako;Murata, Katsuyuki
• 通讯作者: Murata, Katsuyuki

Critical dose of lead affecting postural balance in workers

• DOI: 10.1002/ajim.20220
• 发表时间: 2005-11-01
• 期刊: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
• 影响因子: 3.5
• 作者: Iwata, T;Yano, E;Murata, K
• 通讯作者: Murata, K

Cardiac autonomic hypofunction in presechool children with short nocturnal sleep

学龄前儿童夜间睡眠时间短的心脏自主神经功能低下

• 发表时间: 2006
• 期刊: Tohoku J Exp Med 208
• 作者: M. Masuda;et. al.;Mari Sampei et al.
• 通讯作者: Mari Sampei et al.

Relation between benchmark dose and no-observed-adverse-effect level in clinical research : effects of daily alcohol intake on blood 〜

临床研究中基准剂量与未观察到不良反应水平的关系：每日酒精摄入量对血液的影响~

• 发表时间: 2006
• 期刊: Risk Analysis 26
• 作者: Dakeishi M;Murata K;et al.
• 通讯作者: et al.