South Texas Alzheimer’s Disease Center Population Neuroscience

南德克萨斯阿尔茨海默病中心人口神经科学

• 批准号: 10662335
• 负责人: Claudia L Satizabal
• 金额: $ 12.38万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662335
• 关键词: Address; Agreement; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Assessment tool; Behavioral; Bioinformatics; Biological Markers; Biology; Blood; Brain imaging; Chemicals; Clinical; Cognitive; Collaborations; Communities; Consultations; Data; Dementia; Diabetes Mellitus; Disease; Disparity; Doctor of Philosophy; Education; Etiology; Face; Genome; Genomics; Goals; Health trends; Hispanic Americans; Hispanic Populations; Image; Impaired cognition; Incidence; International; Knowledge; Life Cycle Stages; Life Style; Linguistics; Liquid substance; Magnetic Resonance Imaging; Methods; Mexican Americans; Monitor; Neurosciences; Neurosciences Research; Phenotype; Population; Population Research; Population Study; Positioning Attribute; Positron-Emission Tomography; Prevalence; Preventive measure; Process; Proteome; Protocols documentation; Public Health; Qualitative Research; Recommendation; Reduce health disparities; Research; Research Methodology; Research Personnel; Resource Sharing; Resources; Risk Factors; Role; Services; Source; South Texas; Training; aging brain; cardiovascular risk factor; cognitive testing; cohort; cost effective; critical period; data harmonization; data integration; data management; data resource; data sharing; disorder risk; disparity reduction; education research; epidemiology study; epigenome; ethnic minority population; health disparity; high risk; hispanic community; improved; innovation; insight; lipidome; metabolome; microbiome; modifiable risk; neuropathology; novel; population based; precision medicine; prevent; protective factors; psychosocial; racial minority population; resilience factor; risk prediction; skills; statistics; tool; transcriptome; wearable device

ABSTRACT – Population Neuroscience Core The Population Neuroscience Core (PNC) of the South Texas Alzheimer’s Center (STAC) aims to advance our understanding of the life course factors contributing to Alzheimer’s Disease and Related Dementias, particularly in the understudied population of Mexican American Hispanic, who face an increased risk of the disease. To achieve this goal, our team will conduct cutting-edge epidemiological and neuroscience research to monitor the prevalence and incidence trends of health disparities in dementia, identify life-course risk and protective factors contributing to dementia, identify suitable and cost-effective biomarkers for risk prediction, and the develop culturally and linguistically appropriate tools for cognitive assessment in Mexican Americans from South Texas. The PNC has exceptional resources from existing longitudinal population-based cohorts, new studies focusing on Mexican Americans with deep phenotyping, and established national and international collaborations. The PNC aims to additionally close the gap of representation of Mexican Americans in epidemiological research. This will be achieved by the creation of a PNC sharing resource, where harmonized data to UDS and other standards in dementia research will be shared with other ADRCs and the scientific community. This setting allows the PNC to provide cognitively healthy controls for the Clinical and Neuropathological Cores as well as other ADRCs. Finally, we will train MDs, PhDs, and other professionals in population neuroscience, to develop skills in quantitative and qualitative research methods by leveraging local and national level data. The PNC will develop these aims in close collaboration with all STAC Cores. In summary, the PNC strategically positioned to be a national resource of valuable data from Mexican American Hispanics living in South Texas, and an asset to collaborative research centered on Alzheimer’s and related dementias research. We are fully integrated with the other STAC Cores to provide knowledge, data, services, tools, and training to investigators across the Center, as well as the broader ADRC and scientific community.

摘要 - 人群神经科学核心 南德克萨斯州阿尔茨海默氏症中心（STAC）的人口神经科学核心（PNC）旨在促进我们的 了解生命过程的因素，导致阿尔茨海默氏病和相关痴呆症， 特别是在墨西哥裔美国西班牙裔墨西哥裔人口中，面临的风险增加了 疾病。为了实现这一目标，我们的团队将进行尖端的流行病学和神经科学研究 监测痴呆症健康差异的患病率和发病率趋势，确定生命过程的风险和 促进痴呆症的保护因素，确定适合风险预测的合适且具有成本效益的生物标志物， 以及在文化和语言上发展的适合墨西哥裔美国人认知评估的工具 来自南德克萨斯州。 PNC拥有现有的基于纵向人群的同伙的卓越资源， 新的研究重点是具有深层表型的墨西哥裔美国人，并建立了国家和国际 协作。 PNC的目的是缩小墨西哥裔美国人代表的差距 流行病学研究。这将通过创建PNC共享资源来实现，并在其中协调一致 痴呆症研究中UDS和其他标准的数据将与其他ADRC共享 社区。这种设置使PNC可以为临床和 神经病理核心以及其他ADRC。最后，我们将培训MD，Phds和其他专业人员 人群神经科学，通过利用当地的方式发展定量和定性研究方法的技能 和国家级别的数据。 PNC将与所有STAC核心密切合作开发这些目标。 总而言之，PNC在战略上定位是墨西哥有价值数据的国家资源 居住在德克萨斯州南部的美国西班牙裔美国人，以及以阿尔茨海默氏症的为中心的合作研究的资产 相关痴呆症研究。我们已与其他Stac内核完全集成，以提供知识，数据， 为中心的调查人员以及更广泛的ADRC和科学的服务，工具和培训 社区。